Title:
PREPARATION METHOD FOR BIOTINYLATED HEPARIN PENTASACCHARIDE CAPABLE OF BEING NEUTRALIZED AND USE
Document Type and Number:
WIPO Patent Application WO/2024/061271
Kind Code:
A1
Abstract:
Disclosed is a biotinylated heparin pentasaccharide capable of being neutralized, which has a structure as represented by formula (I). The anti-coagulation activity of the biotinylated heparin pentasaccharide capable of being neutralized similar to that of fondaparinux is shown, and the biotinylated heparin pentasaccharide can be quickly neutralized by avidin.
Inventors:
LI TIEHAI (CN)
ZHANG LIANGWEI (CN)
MA WENJING (CN)
ZHANG LIANGWEI (CN)
MA WENJING (CN)
Application Number:
PCT/CN2023/120057
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07H15/26; A61K31/702; A61K31/7042; A61P7/02; C07H1/00; C07H15/02
Foreign References:
CN101636417A | 2010-01-27 | |||
CN113164660A | 2021-07-23 | |||
CN114957354A | 2022-08-30 | |||
US20200355692A1 | 2020-11-12 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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