Title:
PHYSICAL GEL ON BASIS OF ZWITTERIONIC MODIFIED POLYSACCHARIDE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/001149
Kind Code:
A1
Abstract:
Disclosed in the present invention are a physical gel on the basis of a zwitterionic modified polysaccharide and a preparation method therefor. The method comprises the following steps: (1) preparing a macromolecular initiator (D-Br); (2) preparing a zwitterionic grafted modified polysaccharide derivative; and (3) preparing a physical gel on the basis of a zwitterionic modified polysaccharide. In the present invention, the control of the degree of polymerization n can be achieved by means of using the ATRP method of high molecular polymerization, so that the degree of polymerization of zwitterionic side chains is precisely regulated and controlled, and the magnitude of the ion interaction force is further controlled. Therefore, the phase transformation of "solution-gel-precipitation" of the polymer in a gradient salt ion solution is achieved. A prescription having sensitivity for a physiological solution is screened, and a biodegradable zwitterionic polysaccharide-based hydrogel is prepared.
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Inventors:
YE LEI (CN)
HUANG SUSU (CN)
FANG YUELIN (CN)
HUANG SUSU (CN)
FANG YUELIN (CN)
Application Number:
PCT/CN2023/070719
Publication Date:
January 04, 2024
Filing Date:
January 05, 2023
Export Citation:
Assignee:
UNIV SHANDONG (CN)
International Classes:
C08J3/075; C08F220/36; C08F220/38; C08F251/00; C08K3/16; C08L51/02
Foreign References:
| CN115073770A | 2022-09-20 | |||
| CN103319661A | 2013-09-25 | |||
| CN109280129A | 2019-01-29 |
Other References:
" Doctoral Dissertations", 1 May 2016, TIANJIN UNIVERSITY, China, article YE, LEI: "Zwitterionic Modified Starch Derivatives,Preparation and Application in Drug Delivery and Implants ", pages: 1 - 155, XP009551529
YE, LEI ET AL.: "Physical Cross-Linking Starch-Based Zwitterionic Hydrogel Exhibiting Excellent Biocompatibility, Protein Resistance, and Biodegradability", ACS APPLIED MATERIALS & INTERFACES, vol. 8, 1 June 2016 (2016-06-01), XP055727516, ISSN: 1944-8244, DOI: 10.1021/acsami.6b03098
FANGLIAN YAO, GUO QI; LUO QIAOYUE; TIAN MIAO; WANG JINMEI: "Synthesis of Agarose-Based Zwitterionic Polymer and Its Anti-Polyelectrolyte Behavior", TIANJIN DAXUE XUEBAO - JOURNAL OF TIANJIN UNIVERSITY, GAI-KAN BIANJIBU, TIANJIN, CN, vol. 53, no. 2, 14 January 2020 (2020-01-14), CN , pages 201 - 206, XP093122706, ISSN: 0493-2137, DOI: 10.11784/tdxbz201902048
TIAN MIAO, WANG JINMEI, ZHANG ERSHUAI, LI JUNJIE, DUAN CUIMI, YAO FANGLIAN: "Synthesis of Agarose- graft -poly[3-dimethyl (methacryloyloxyethyl) ammonium propanesulfonate] Zwitterionic Graft Copolymers via ATRP and Their Thermally-Induced Aggregation Behavior in Aqueous Media", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 25, 25 June 2013 (2013-06-25), US , pages 8076 - 8085, XP093122707, ISSN: 0743-7463, DOI: 10.1021/la4007668
YE, LEI ET AL.: "Physical Cross-Linking Starch-Based Zwitterionic Hydrogel Exhibiting Excellent Biocompatibility, Protein Resistance, and Biodegradability", ACS APPLIED MATERIALS & INTERFACES, vol. 8, 1 June 2016 (2016-06-01), XP055727516, ISSN: 1944-8244, DOI: 10.1021/acsami.6b03098
FANGLIAN YAO, GUO QI; LUO QIAOYUE; TIAN MIAO; WANG JINMEI: "Synthesis of Agarose-Based Zwitterionic Polymer and Its Anti-Polyelectrolyte Behavior", TIANJIN DAXUE XUEBAO - JOURNAL OF TIANJIN UNIVERSITY, GAI-KAN BIANJIBU, TIANJIN, CN, vol. 53, no. 2, 14 January 2020 (2020-01-14), CN , pages 201 - 206, XP093122706, ISSN: 0493-2137, DOI: 10.11784/tdxbz201902048
TIAN MIAO, WANG JINMEI, ZHANG ERSHUAI, LI JUNJIE, DUAN CUIMI, YAO FANGLIAN: "Synthesis of Agarose- graft -poly[3-dimethyl (methacryloyloxyethyl) ammonium propanesulfonate] Zwitterionic Graft Copolymers via ATRP and Their Thermally-Induced Aggregation Behavior in Aqueous Media", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 25, 25 June 2013 (2013-06-25), US , pages 8076 - 8085, XP093122707, ISSN: 0743-7463, DOI: 10.1021/la4007668
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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