Title:
PEPTIDE-IMMOBILIZED BEAD LIBRARY
Document Type and Number:
WIPO Patent Application WO/2023/100976
Kind Code:
A1
Abstract:
Disclosed is a peptide-immobilized bead library which, in comparison to well-known OPOB libraries, has a higher potential for an obtained peptide to become a useful substance candidate for a drug or the like, and makes it easier to analyze an amino acid sequence bonded to a target substance. The peptide-immobilized bead library has a structure represented by formula [I]. In general formula [I], X represents an amino acid residue, n represents an integer of 4-8, Y represents a cyclic structure, A represents a spacer structure, B represents a specific cleavage site-containing structure, and the 4-8 amino acid residues represented by X are randomly selected independently of each other.
Inventors:
NOKIHARA KIYOSHI (JP)
SASAKI TORU (JP)
KASAMA TAKESHI (JP)
SASAKI TORU (JP)
KASAMA TAKESHI (JP)
Application Number:
PCT/JP2022/044358
Publication Date:
June 08, 2023
Filing Date:
December 01, 2022
Export Citation:
Assignee:
HIPEP LABORATORIES (JP)
International Classes:
C40B40/10; C07K5/12; C07K7/54; C07K7/64; C07K17/00; G01N33/545
Foreign References:
| US20150078999A1 | 2015-03-19 |
Other References:
LIU TAO, QIAN ZIQING, XIAO QING, PEI DEHUA: "High-Throughput Screening of One-Bead-One-Compound Libraries: Identification of Cyclic Peptidyl Inhibitors against Calcineurin/NFAT Interaction", ACS COMBINATIONAL SCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 5, 12 September 2011 (2011-09-12), US , pages 537 - 546, XP093070125, ISSN: 2156-8952, DOI: 10.1021/co200101w
ZHENG XUEJUN, LIU WEIDONG, LIU ZIYAN, ZHAO YIBING, WU CHUANLIU: "Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 9, 16 September 2020 (2020-09-16), US , pages 2085 - 2091, XP093070130, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00363
NOKIHARA KIYOSHI; KASAMA TAKESHI; TOMINAGA YUKI; KITAGAWA ATSUSHI; HIRATA AKIYOSHI; OHYAMA TAKAFUMI; YAZAWA ITARU: "High throughput sequencing of cyclic peptide immobilized on a gel-type single bead", AMINO ACIDS., SPRINGER VERLAG., AU, vol. 48, no. 11, 8 June 2016 (2016-06-08), AU , pages 2491 - 2499, XP036081373, ISSN: 0939-4451, DOI: 10.1007/s00726-016-2269-1
ZHENG XUEJUN, LIU WEIDONG, LIU ZIYAN, ZHAO YIBING, WU CHUANLIU: "Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 9, 16 September 2020 (2020-09-16), US , pages 2085 - 2091, XP093070130, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00363
NOKIHARA KIYOSHI; KASAMA TAKESHI; TOMINAGA YUKI; KITAGAWA ATSUSHI; HIRATA AKIYOSHI; OHYAMA TAKAFUMI; YAZAWA ITARU: "High throughput sequencing of cyclic peptide immobilized on a gel-type single bead", AMINO ACIDS., SPRINGER VERLAG., AU, vol. 48, no. 11, 8 June 2016 (2016-06-08), AU , pages 2491 - 2499, XP036081373, ISSN: 0939-4451, DOI: 10.1007/s00726-016-2269-1
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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