Title:
PEPTIDE, AND CELL FUSION AGENT AND PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY CONTAINING SAID PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2022/202785
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide a method for efficient cell fusion. Also, a purpose of the present invention is to provide a method for killing cancer cells or a method for fusing a viral envelope by membrane fusion. The foregoing can be achieved by: (1) a polypeptide, which includes an amino acid sequence having a group represented by formula (I): -Z-Xm-Y (I) (in the formula: Z is a hydrophilic linker; X is a hydrophilic amino acid residue selected from the group consisting of serine, threonine, asparagine, glutamine, arginine, histidine, lysine, aspartic acid, glutamic acid, tyrosine and cysteine; Y is a carboxyl group or an amino group; m is an integer 1-5; and, when m is 2-5, the hydrophilic amino acid residues may be the same or may be the combination or different amino acid residues) at the N-terminal of an amino acid sequence selected from the group consisting of amino acid sequences represented by SEQ ID NOs: 1-8; or (2) a polypeptide, which includes an amino acid sequence having a group represented by the formula (I) at the N-terminal of an amino acid sequence in which 1-4 amino acids have been deleted, substituted, inserted and/or added in an amino acid sequence represented by SEQ ID NOs: 1-8 and which has cell fusion activity or viral envelope fusion activity.
Inventors:
KOGA MICHIKO (JP)
Application Number:
PCT/JP2022/013074
Publication Date:
September 29, 2022
Filing Date:
March 22, 2022
Export Citation:
Assignee:
KOGA MICHIKO (JP)
International Classes:
C07K4/00; A61K38/10; A61P35/00; C07K16/00
Domestic Patent References:
| WO2021054448A1 | 2021-03-25 | |||
| WO2003099862A1 | 2003-12-04 | |||
| WO2011063128A1 | 2011-05-26 |
Foreign References:
| JP2008532549A | 2008-08-21 | |||
| US20190284240A1 | 2019-09-19 | |||
| JP2008505854A | 2008-02-28 |
Other References:
MURATA, MASAYUKI: "Functional and structural aspects of fusion peptide", MEMBRAME, KITAMI SHOBO, TOKYO., JP, vol. 19, no. 4, 1 July 1994 (1994-07-01), JP , pages 221 - 230, XP009539969, ISSN: 0385-1036, DOI: 10.5360/membrane.19.221
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
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