Title:
PEPTIDE-BOUND HYBRID LIPOSOME EXOSOME, PEPTIDE-BOUND EXOSOME, COMPOSITION CONTAINING THESE, AND METHOD FOR FORMING SAME
Document Type and Number:
WIPO Patent Application WO/2023/027082
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a hybrid liposome exosome or the like capable of delivering an active ingredient to a target cell at a higher concentration. This peptide-bound hybrid liposome exosome, which includes, in a lipid bilayer, an exosome marker protein selected from CD63, CD81, and CD9, and a peptide-bound lipid derivative in which a peptide is bound to a hydrophilic portion of a composite lipid, can provide an additional function concerning the endosomal escape of the peptide-bound hybrid liposome exosome after being taken into an endosome of a target cell, whereby a carrier that is for a drug delivery system and that is capable of delivering an active ingredient to a target cell at a higher concentration can be provided.
Inventors:
TAN ZHELI (JP)
Application Number:
PCT/JP2022/031768
Publication Date:
March 02, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
SEKISUI CHEMICAL CO LTD (JP)
International Classes:
C07K17/02; A61K35/12; A61K45/00; A61K47/69; A61P43/00; C07K7/06; C07K7/08; C07K14/705; C12N5/071; C12N5/0735; C12N5/0775; C12N15/11; C12Q1/24; G01N33/53
Domestic Patent References:
| WO2020219563A1 | 2020-10-29 | |||
| WO2016167367A1 | 2016-10-20 | |||
| WO2021211460A1 | 2021-10-21 |
Foreign References:
| JP2019218349A | 2019-12-26 | |||
| JP2020531018A | 2020-11-05 | |||
| JP2017535599A | 2017-11-30 | |||
| JP2021506795A | 2021-02-22 | |||
| JP2021503300A | 2021-02-12 | |||
| JP2021135828A | 2021-09-13 | |||
| JP6137894B2 | 2017-05-31 |
Other References:
SEVERIC MAJA, MA GUANGLONG, PEREIRA SARA G T, RUIZ AMALIA, CHEUNG CALVIN C.L., AL-JAMAL WAFA T.: "Genetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 330, 1 February 2021 (2021-02-01), AMSTERDAM, NL , pages 101 - 110, XP093038440, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.12.017
YUKO T. SATO, KAORI UMEZAKI, SHINICHI SAWADA, SADA-ATSU MUKAI, YOSHIHIRO SASAKI, NAOZUMI HARADA, HIROSHI SHIKU, KAZUNARI AKIYOSHI: "Engineering hybrid exosomes by membrane fusion with liposomes", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 April 2016 (2016-04-01), XP055701441, DOI: 10.1038/srep21933
JUNSUNG LEE, HYOUNGJIN LEE, UNBYEOL GOH, JIYOUNG KIM, MOONKYOUNG JEONG, JEAN LEE, JI-HO PARK: "Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 11, 23 March 2016 (2016-03-23), US , pages 6790 - 6795, XP055598701, ISSN: 1944-8244, DOI: 10.1021/acsami.6b01315
INT. J. MOL. SCI., vol. 20, 2019, pages 2167
NAT. REV. MOL. CELL BIOL., vol. 19, 2018, pages 281
NAKAI, W. ET AL.: "A novel affinity-based method for the isolation of highly purified extracellular vesicles", SCI. REP., vol. 6, pages 33935, XP055561243, DOI: 10.1038/srep33935
JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 91, no. 4, 2019, pages 514 - 518
YUKO T. SATO, KAORI UMEZAKI, SHINICHI SAWADA, SADA-ATSU MUKAI, YOSHIHIRO SASAKI, NAOZUMI HARADA, HIROSHI SHIKU, KAZUNARI AKIYOSHI: "Engineering hybrid exosomes by membrane fusion with liposomes", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 April 2016 (2016-04-01), XP055701441, DOI: 10.1038/srep21933
JUNSUNG LEE, HYOUNGJIN LEE, UNBYEOL GOH, JIYOUNG KIM, MOONKYOUNG JEONG, JEAN LEE, JI-HO PARK: "Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 11, 23 March 2016 (2016-03-23), US , pages 6790 - 6795, XP055598701, ISSN: 1944-8244, DOI: 10.1021/acsami.6b01315
INT. J. MOL. SCI., vol. 20, 2019, pages 2167
NAT. REV. MOL. CELL BIOL., vol. 19, 2018, pages 281
NAKAI, W. ET AL.: "A novel affinity-based method for the isolation of highly purified extracellular vesicles", SCI. REP., vol. 6, pages 33935, XP055561243, DOI: 10.1038/srep33935
JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 91, no. 4, 2019, pages 514 - 518
Attorney, Agent or Firm:
MIYAJIMA Manabu et al. (JP)
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