Title:
OPHTHALMIC PHARMACEUTICAL COMPOSITION CONTAINING LEVAMISOLE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/078515
Kind Code:
A1
Abstract:
The present invention relates to an ophthalmic pharmaceutical composition containing levamisole, a preparation method therefor, and a use thereof, and in particular relates to an ophthalmic preparation. The ophthalmic preparation comprises levamisole or a pharmaceutically-acceptable salt thereof as an active ingredient and water, the concentration of levamisole or the pharmaceutically-acceptable salt thereof being 0.01%-10% (w/v). The ophthalmic preparation can promote tear secretion and increase the number of conjunctival goblet cells, can effectively improve dry eye syndrome, corneal epithelium injury and tear film stability of a patient, and can alleviate and/or improve dry eye diseases and/or treat dry eyes, including but not limited to ocular diseases such as dry eye-related ocular surface inflammation, meibomian gland dysfunction, lacrimal gland inflammation, fibrosis, conjunctivitis, etc.
Inventors:
LIU ZUGUO (CN)
HUANG CAIHONG (CN)
ZHENG XIAOXIANG (CN)
HUANG CAIHONG (CN)
ZHENG XIAOXIANG (CN)
Application Number:
PCT/CN2023/123885
Publication Date:
April 18, 2024
Filing Date:
October 11, 2023
Export Citation:
Assignee:
XIAMEN SHANGJIAYUAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K9/08; A61K31/429; A61K47/02; A61K47/10; A61K47/12; A61K47/26; A61P27/02
Foreign References:
| CN115518036A | 2022-12-27 | |||
| CA1112170A | 1981-11-10 |
Other References:
"Shanghai Practical Handbook of Drugs", 31 July 1992, WENHUI PUBLISHING HOUSE, CN, ISBN: 7-80531-194-3, article SHEN, YUNSUN ET AL.: "Levamisole Hydrochloride", pages: 1416, XP009554147
许英民 (XU, YINGMIN): "犬眼虫病的防治体会 (Non-official translation: Experience in Prevention and Treatment of Canine Eyeworm Disease)", 今日畜牧兽医 (NON-OFFICIAL TRANSLATION: HEBEI XUMU SHOUYI), no. 8, 31 December 2010 (2010-12-31)
何守志 (HE, SHOUZHI): "眼免疫学 (Non-official translation: Ocular Immunology)", 临床眼科学 (NON-OFFICIAL TRANSLATION: CLINICAL OPHTHALMOLOGY), 31 January 2002 (2002-01-31), pages 258 - 259
李俊轩等 (LI, JUNXUAN ET AL.): "滴眼液与洗眼剂 (Non-official translation: Eye Drops and Eyewash)", 新编实用药物制剂及合理应用 (NON-OFFICIAL TRANSLATION: NEW PRACTICAL PHARMACEUTICAL PREPARATIONS AND RATIONAL APPLICATION), 31 January 2006 (2006-01-31), pages 427 - 428
LI QINGHUANG: "Observation on the Efficacy of Cyclosporine A Combined With Levamisole in the Treatment of Dry Eye Disease in 108 Cases", SHANDONG MEDICAL JOURNAL, vol. 46, no. 25, 5 September 2006 (2006-09-05), XP093159552
PANG, YOUJIAN: "Treating Terpes Simplex Keratitis With Levamisole", CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY (CHIN. J. EXP. OPHTHALMOL.), vol. 1, no. 2, 31 December 1980 (1980-12-31), pages 135 - 136, XP009554105, ISSN: 2095-0160
许英民 (XU, YINGMIN): "犬眼虫病的防治体会 (Non-official translation: Experience in Prevention and Treatment of Canine Eyeworm Disease)", 今日畜牧兽医 (NON-OFFICIAL TRANSLATION: HEBEI XUMU SHOUYI), no. 8, 31 December 2010 (2010-12-31)
何守志 (HE, SHOUZHI): "眼免疫学 (Non-official translation: Ocular Immunology)", 临床眼科学 (NON-OFFICIAL TRANSLATION: CLINICAL OPHTHALMOLOGY), 31 January 2002 (2002-01-31), pages 258 - 259
李俊轩等 (LI, JUNXUAN ET AL.): "滴眼液与洗眼剂 (Non-official translation: Eye Drops and Eyewash)", 新编实用药物制剂及合理应用 (NON-OFFICIAL TRANSLATION: NEW PRACTICAL PHARMACEUTICAL PREPARATIONS AND RATIONAL APPLICATION), 31 January 2006 (2006-01-31), pages 427 - 428
LI QINGHUANG: "Observation on the Efficacy of Cyclosporine A Combined With Levamisole in the Treatment of Dry Eye Disease in 108 Cases", SHANDONG MEDICAL JOURNAL, vol. 46, no. 25, 5 September 2006 (2006-09-05), XP093159552
PANG, YOUJIAN: "Treating Terpes Simplex Keratitis With Levamisole", CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY (CHIN. J. EXP. OPHTHALMOL.), vol. 1, no. 2, 31 December 1980 (1980-12-31), pages 135 - 136, XP009554105, ISSN: 2095-0160
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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