Title:
NUCLEOSIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/224108
Kind Code:
A1
Abstract:
Provided is a nucleoside represented by formula (1). [In formula (1): R1 represents a hydroxyl group, a hydroxyl group in which the hydrogen atom is substituted by an alkyl or alkenyl group, or a protected hydroxyl group; R2 represents a hydrogen atom, a protecting group of the hydroxyl group, a phosphate group, a protected phosphate group, a protected phosphorothioate group or -P(=O)nR5R6 (wherein n represents 0 or 1, and R5 and R6 are the same as or different from each other and represent any of a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, a lower alkoxy group, a cyano lower alkoxy group, an amino group or a substituted amino group, provided that when n is 1, then R5 and R6 cannot both be hydrogen atoms); R3 represents a hydrogen atom, a protecting group of the hydroxyl group, a phosphate group, a protected phosphate group or a phosphorothioate group; R4 represents a hydroxyl group, a protected hydroxyl group, an azide group or NHR7; R7 represents a hydrogen atom or a protecting group of the amino group; and B represents a purine base or a pyrimidine base.]
Inventors:
UENO YOSHIHITO (JP)
KAJINO RYOHEI (JP)
CHANO TOKUHIRO (JP)
FURUICHI YASUHIRO (JP)
KAWADE MIWA (JP)
KAKIZAWA YURI (JP)
SAKAMOTO SHUICHI (JP)
KAJINO RYOHEI (JP)
CHANO TOKUHIRO (JP)
FURUICHI YASUHIRO (JP)
KAWADE MIWA (JP)
KAKIZAWA YURI (JP)
SAKAMOTO SHUICHI (JP)
Application Number:
PCT/JP2023/018672
Publication Date:
November 23, 2023
Filing Date:
May 18, 2023
Export Citation:
Assignee:
GF MILLE CO LTD (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
MICROBIAL CHEM RES FOUND (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
MICROBIAL CHEM RES FOUND (JP)
International Classes:
C07H19/067; C07H19/167; C07H19/173; C07H23/00; C12N15/113
Domestic Patent References:
| WO2015164693A1 | 2015-10-29 |
Other References:
KAJINO RYOHEI, MAEDA YUSUKE, YOSHIDA HISAE, YAMAGISHI KENJI, UENO YOSHIHITO: "Synthesis and Biophysical Characterization of RNAs Containing ( R )- and ( S )-5′- C -Aminopropyl-2′- O -methyluridines", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 84, no. 6, 15 March 2019 (2019-03-15), pages 3388 - 3404, XP093109480, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b03277
Attorney, Agent or Firm:
KAI-U PATENT LAW FIRM (JP)
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