Title:
NUCLEOCAPSID-DERIVED ANTIGEN PEPTIDE, NUCLEIC ACID, VECTOR, PHARMACEUTICAL COMPOSITION, HLA/ANTIGEN PEPTIDE COMPLEX, AND METHOD FOR DETECTING T CELL
Document Type and Number:
WIPO Patent Application WO/2024/085143
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel peptide that could be used to induce an immune response to SARS-CoV-2. A nucleocapsid-derived antigen peptide according to the present disclosure includes the following polypeptide (P1), (P2) or (P3): (P1) a polypeptide comprising an amino acid sequence represented by SEQ ID NO: 1 (KAYNVTQAF); (P2) a polypeptide comprising an amino acid sequence obtained by deleting, inserting, substituting, or adding 1-6 amino acids in the amino acid sequence represented by SEQ ID NO: 1; and (P3) a polypeptide comprising an amino acid sequence having at least 80% identity to the amino acid sequence represented by SEQ ID NO: 1.
Inventors:
MOTOZONO CHIHIRO (JP)
UENO TAKAMASA (JP)
GOTO YOSHIHIKO (JP)
KISHI HIROYUKI (JP)
HAMANA HIROSHI (JP)
UENO TAKAMASA (JP)
GOTO YOSHIHIKO (JP)
KISHI HIROYUKI (JP)
HAMANA HIROSHI (JP)
Application Number:
PCT/JP2023/037529
Publication Date:
April 25, 2024
Filing Date:
October 17, 2023
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
International Classes:
C12N15/50; A61K38/16; A61K39/00; A61K39/395; A61P31/14; A61P37/04; A61P43/00; C07K14/165; C07K14/74; C07K19/00; C12N15/63; C12Q1/04
Domestic Patent References:
| WO2021163371A1 | 2021-08-19 | |||
| WO2022148455A1 | 2022-07-14 | |||
| WO2021195108A1 | 2021-09-30 | |||
| WO2022149549A1 | 2022-07-14 |
Foreign References:
| JP2022017865A | 2022-01-26 |
Other References:
AKSHAY AGARWAL: "Predicting Epitope Candidates for SARS-CoV-2", VIRUSES, MDPI, CH, vol. 14, no. 8, CH , pages 1837, XP093161023, ISSN: 1999-4915, DOI: 10.3390/v14081837
GRIFONI ALBA; SIDNEY JOHN; ZHANG YUN; SCHEUERMANN RICHARD H.; PETERS BJOERN; SETTE ALESSANDRO: "A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2", CELL HOST & MICROBE, ELSEVIER, NL, vol. 27, no. 4, 16 March 2020 (2020-03-16), NL , pages 671 - 680, XP086125935, ISSN: 1931-3128, DOI: 10.1016/j.chom.2020.03.002
ETHAN FAST, RUSS B. ALTMAN, BINBIN CHEN: "Significance Statement", BIORXIV, 18 March 2020 (2020-03-18), XP055716967, DOI: 10.1101/2020.02.19.955484
GRIFONI ALBA; SIDNEY JOHN; ZHANG YUN; SCHEUERMANN RICHARD H.; PETERS BJOERN; SETTE ALESSANDRO: "A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2", CELL HOST & MICROBE, ELSEVIER, NL, vol. 27, no. 4, 16 March 2020 (2020-03-16), NL , pages 671 - 680, XP086125935, ISSN: 1931-3128, DOI: 10.1016/j.chom.2020.03.002
ETHAN FAST, RUSS B. ALTMAN, BINBIN CHEN: "Significance Statement", BIORXIV, 18 March 2020 (2020-03-18), XP055716967, DOI: 10.1101/2020.02.19.955484
Attorney, Agent or Firm:
IP Law Firm Lexceed Tech (JP)
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