Title:
NOVEL RETINOIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION INCLUDING THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/168607
Kind Code:
A1
Abstract:
A compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof are provided, wherein the compound includes a retinoic acid conjugated with a carbohydrate. In addition, use of the compound or the pharmaceutically acceptable salt thereof or the pharmaceutical composition in the manufacture of a medicament for inhibiting infection or replication of a virus or for treating a cancer is also provided.
Inventors:
CHEN CHING-YU (CN)
LIN BO-LIN (CN)
LIN BO-LIN (CN)
Application Number:
PCT/CN2022/079791
Publication Date:
September 14, 2023
Filing Date:
March 08, 2022
Export Citation:
Assignee:
MASTERY BIOTECH CO LTD (CN)
International Classes:
C07H3/02; A61K31/203; A61P31/14; A61P35/00
Domestic Patent References:
| WO2021202014A1 | 2021-10-07 |
Foreign References:
| BRPI0805754A2 | 2010-09-14 |
Other References:
DATABASE REGISTRY 12 September 2004 (2004-09-12), ANONYMOUS: "Retinamide, N-[2-(β-D-glucopyranuronosyloxy)ethyl]- (9CI) (CA INDEX NAME)", XP093090239, retrieved from STNext Database accession no. 743374-51-8
XIANG JIAN‐NAN, JIANG LI‐HUI, CHEN CHAO‐YUE, FU ZHI‐YING, DUAN JUN‐FEI, HE XIAO‐XIAO, WANG KE‐MIN: "Studies on the Synthesis and Antiproliferative Activities of 13‐ cis ‐Retinoyl Sugar Derivatives", JOURNAL OF CARBOHYDRATE CHEMISTRY, TAYLOR & FRANCIS, UK, vol. 25, no. 7, 1 September 2006 (2006-09-01), UK , pages 595 - 614, XP093090091, ISSN: 0732-8303, DOI: 10.1080/07328300600966497
JIAN-NAN XIANG, CHEN CHAO-YUE, JIANG LI-HUI, ZHOU HOU-XIANG, YIN KAI, DENG XIAO-QIANG, CHEN JING, HE XIAO-XIAO, WANG KE-MIN: "Studies on the synthesis and cytotoxic activities of 13-cis-retinoyl sugar derivatives.", CHEMICAL JOURNAL OF CHINESE UNIVERSITY, vol. 28, no. 8, 1 August 2007 (2007-08-01), pages 1497 - 1502, XP093090093
DAWSON MARCIA I., PETER D. HOBBS: "Synthesis of the D-glucuronic acid conjugates of N-(4-hydroxyphenyl)- and N-(2-hydroxyethyl)-retinamides", CARBOHYDRATE RESEARCH, vol. 85, 1 January 1980 (1980-01-01), pages 121 - 129, XP093090096
ELKAZZAZ MAHMOUD, TAMER HAYDARA, MOHAMED ABDELAAL, ABEDELAZIZ ELSAYED ,YOUSRY ABO-AMER, HESHAM ATTIA, QUAN LIU, TIM DUONG, HEBA SA: "Study Details | Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) | ClinicalTrials.gov", CLINICALTRIALS.GOV ID NCT04353180, 29 July 2021 (2021-07-29), XP093090209, Retrieved from the Internet [retrieved on 20231010]
HUNTER JENNIFER, ARENTZ SUSAN, GOLDENBERG JOSHUA, YANG GUOYAN, BEARDSLEY JENNIFER, MYERS STEPHEN P, MERTZ DOMINIK, LEEDER STEPHEN: "Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials", BMJ OPEN, BMJ PUBLISHING GROUP, LONDON, UK, vol. 11, no. 11, 1 October 2021 (2021-10-01), London, UK , pages e047474, XP093090211, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2020-047474
XIANG JIAN‐NAN, JIANG LI‐HUI, CHEN CHAO‐YUE, FU ZHI‐YING, DUAN JUN‐FEI, HE XIAO‐XIAO, WANG KE‐MIN: "Studies on the Synthesis and Antiproliferative Activities of 13‐ cis ‐Retinoyl Sugar Derivatives", JOURNAL OF CARBOHYDRATE CHEMISTRY, TAYLOR & FRANCIS, UK, vol. 25, no. 7, 1 September 2006 (2006-09-01), UK , pages 595 - 614, XP093090091, ISSN: 0732-8303, DOI: 10.1080/07328300600966497
JIAN-NAN XIANG, CHEN CHAO-YUE, JIANG LI-HUI, ZHOU HOU-XIANG, YIN KAI, DENG XIAO-QIANG, CHEN JING, HE XIAO-XIAO, WANG KE-MIN: "Studies on the synthesis and cytotoxic activities of 13-cis-retinoyl sugar derivatives.", CHEMICAL JOURNAL OF CHINESE UNIVERSITY, vol. 28, no. 8, 1 August 2007 (2007-08-01), pages 1497 - 1502, XP093090093
DAWSON MARCIA I., PETER D. HOBBS: "Synthesis of the D-glucuronic acid conjugates of N-(4-hydroxyphenyl)- and N-(2-hydroxyethyl)-retinamides", CARBOHYDRATE RESEARCH, vol. 85, 1 January 1980 (1980-01-01), pages 121 - 129, XP093090096
ELKAZZAZ MAHMOUD, TAMER HAYDARA, MOHAMED ABDELAAL, ABEDELAZIZ ELSAYED ,YOUSRY ABO-AMER, HESHAM ATTIA, QUAN LIU, TIM DUONG, HEBA SA: "Study Details | Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) | ClinicalTrials.gov", CLINICALTRIALS.GOV ID NCT04353180, 29 July 2021 (2021-07-29), XP093090209, Retrieved from the Internet
HUNTER JENNIFER, ARENTZ SUSAN, GOLDENBERG JOSHUA, YANG GUOYAN, BEARDSLEY JENNIFER, MYERS STEPHEN P, MERTZ DOMINIK, LEEDER STEPHEN: "Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials", BMJ OPEN, BMJ PUBLISHING GROUP, LONDON, UK, vol. 11, no. 11, 1 October 2021 (2021-10-01), London, UK , pages e047474, XP093090211, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2020-047474
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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