Title:
NOVEL PURINE DERIVATIVE COMPOUNDS AS A3 ADENOSINE RECEPTOR AGONISTS
Document Type and Number:
WIPO Patent Application WO/2024/029877
Kind Code:
A1
Abstract:
The present invention provides novel purine derivative compounds as A3 adenosine receptor agonists, hydrates thereof, solvates thereof, or pharmaceutically acceptable salts thereof. The novel purine derivatives of the present invention have been identified to exhibit excellent activity as A3 adenosine receptor agonists and exhibit therapeutic effects on pulmonary fibrosis and accordingly, it has been revealed that A3 adenosine receptor agonists can be used for the prevention or treatment of pulmonary fibrosis. Therefore, the novel purine derivative compounds of the present invention can be advantageously used for the prevention or treatment of diseases related to A3 adenosine receptors. Furthermore, A3 adenosine receptor agonists, including the novel purine derivative compounds of the present invention, can be advantageously used for the prevention or treatment of pulmonary fibrosis.
Inventors:
LEE BONG YONG (KR)
NAM GYEONG SUG (KR)
CHO YOUNG KYOUNG (KR)
KIM A REUM (KR)
SHIN YOUNG AH (KR)
CHO JAE HO (KR)
LEE YOON JIN (KR)
KIM JI HEE (KR)
NAM JAE KYUNG (KR)
KIM KWANG SEOK (KR)
NAM GYEONG SUG (KR)
CHO YOUNG KYOUNG (KR)
KIM A REUM (KR)
SHIN YOUNG AH (KR)
CHO JAE HO (KR)
LEE YOON JIN (KR)
KIM JI HEE (KR)
NAM JAE KYUNG (KR)
KIM KWANG SEOK (KR)
Application Number:
PCT/KR2023/011169
Publication Date:
February 08, 2024
Filing Date:
July 31, 2023
Export Citation:
Assignee:
NEXTGEN BIOSCIENCE CO LTD (KR)
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
UNIV YONSEI IACF (KR)
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
UNIV YONSEI IACF (KR)
International Classes:
C07D473/34; A61K31/52; A61K31/7076; A61P11/00; A61P43/00; C07H19/16
Foreign References:
| KR20020064327A | 2002-08-07 | |||
| KR20100029002A | 2010-03-15 |
Other References:
SGAMBELLONE SILVIA, MARRI SILVIA, CATARINICCHIA STEFANO, PINI ALESSANDRO, TOSH DILIP K., JACOBSON KENNETH A., MASINI EMANUELA, SAL: "Adenosine A3 Receptor (A3AR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 23, no. 21, 1 November 2022 (2022-11-01), Basel, CH , pages 13300, XP093136279, ISSN: 1661-6596, DOI: 10.3390/ijms232113300
MORSCHL EVA, MOLINA JOSE G., VOLMER JONATHAN B., MOHSENIN AMIR, PERO RALPH S., HONG JEONG-SOO, KHERADMAND FARRAH, LEE JAMES J., BL: "A 3 Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 39, no. 6, 1 December 2008 (2008-12-01), NEW YORK, NY, US , pages 697 - 705, XP093136280, ISSN: 1044-1549, DOI: 10.1165/rcmb.2007-0419OC
XIYAN HOU, MAHESH S. MAJIK, KYUNGLIM KIM, YUNA PYEE, YOONJI LEE, VARUGHESE ALEXANDER, HWA-JIN CHUNG, HYUK WOO LEE, GIRISH CHANDRA,: "Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A 2A and A 3 Adenosine Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 55, no. 1, 12 January 2012 (2012-01-12), US , pages 342 - 356, XP055751624, ISSN: 0022-2623, DOI: 10.1021/jm201229j
MORSCHL EVA, MOLINA JOSE G., VOLMER JONATHAN B., MOHSENIN AMIR, PERO RALPH S., HONG JEONG-SOO, KHERADMAND FARRAH, LEE JAMES J., BL: "A 3 Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 39, no. 6, 1 December 2008 (2008-12-01), NEW YORK, NY, US , pages 697 - 705, XP093136280, ISSN: 1044-1549, DOI: 10.1165/rcmb.2007-0419OC
XIYAN HOU, MAHESH S. MAJIK, KYUNGLIM KIM, YUNA PYEE, YOONJI LEE, VARUGHESE ALEXANDER, HWA-JIN CHUNG, HYUK WOO LEE, GIRISH CHANDRA,: "Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A 2A and A 3 Adenosine Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 55, no. 1, 12 January 2012 (2012-01-12), US , pages 342 - 356, XP055751624, ISSN: 0022-2623, DOI: 10.1021/jm201229j
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
Download PDF:
Previous Patent: MODIFIED FUSION PROTEIN AND USE THEREOF
Next Patent: MANAGING ALTERNATE-NETWORK SLICE IN MULTI-SIM UE
Next Patent: MANAGING ALTERNATE-NETWORK SLICE IN MULTI-SIM UE