Title:
NOVEL CYCLIC PENTADEPSIPEPTIDE-BASED COMPOUND AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR REGENERATION OR WOUND HEALING
Document Type and Number:
WIPO Patent Application WO/2022/019657
Kind Code:
A1
Abstract:
The present invention relates to a novel cyclic pentadepsipeptide, a novel microorganism producing same, and a composition comprising the compound as an active ingredient for regeneration or would healing. More specifically, the present invention relates to a pharmaceutical composition for skin regeneration or wound healing, a cosmetic composition for skin regeneration or wound alleviation, a quasi-drug composition for skin regeneration or wound healing, and a health functional food composition for skin regeneration or wound alleviation, each composition comprising acremoitamide, which is a novel cyclic peptadepsipeptide, as an active ingredient. Acremonitamide, which is a novel cyclic peptadepsipeptide isolated from a fungus strain derived from marine deposits according to the present invention, is free of cytotoxicity and thus safe to the skin, and when applied, acremonitamide significantly increases in cellular infiltration ability, forms neoblastic tissues and remarkably reduces scars at wound sites and as such, can be advantageously used in medicinal products, cosmetic products, and foods for skin regeneration and wound healing.
Inventors:
KIM HANG GUN (KR)
PARK SO HYEON (KR)
LEE CHANG WOOK (KR)
NAM SANG JIP (KR)
PARK SO HYEON (KR)
LEE CHANG WOOK (KR)
NAM SANG JIP (KR)
Application Number:
PCT/KR2021/009434
Publication Date:
January 27, 2022
Filing Date:
July 21, 2021
Export Citation:
Assignee:
INDUSTRY ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIV (KR)
International Classes:
C07K11/02; A23L33/18; A61K8/64; A61K38/12; A61K38/15; A61P17/00; A61P17/02; A61Q19/00; C12N1/14
Domestic Patent References:
| WO2012070936A1 | 2012-05-31 |
Foreign References:
| KR20180092837A | 2018-08-20 |
Other References:
ROMANS-FUERTES PATRICIA; SONDERGAARD TEIS ESBEN; SANDMANN MANUELA ILSE; WOLLENBERG RASMUS DAM; NIELSEN KRISTIAN FOG; HANSEN FREDER: "Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide inFusarium solani", CURRENT GENETICS, NEW YORK, NY, US, vol. 62, no. 4, 2 March 2016 (2016-03-02), US , pages 799 - 807, XP036071949, ISSN: 0172-8083, DOI: 10.1007/s00294-016-0584-4
XIAOHAN WANG, XIAO GONG, PENG LI, DAOWAN LAI, LIGANG ZHOU: "Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi", MOLECULES, vol. 23, no. 1, pages 169, XP055662832, DOI: 10.3390/molecules23010169
FU DONGLIN, XUEMIN RAO, JINYI XU, GENZOH TANABE, OSAMU MURAOKA, XIAOMING WU, WEIJIA XIE: "First total synthesis of cyclic pentadepsipeptides Hikiamides A-C", TETRAHEDRON LETTERS, vol. 59, no. 30, 1 February 2018 (2018-02-01), pages 2876 - 2879, XP055889358, DOI: 10.1016/j.tetlet.2018.01.096
XIAOHAN WANG, XIAO GONG, PENG LI, DAOWAN LAI, LIGANG ZHOU: "Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi", MOLECULES, vol. 23, no. 1, pages 169, XP055662832, DOI: 10.3390/molecules23010169
FU DONGLIN, XUEMIN RAO, JINYI XU, GENZOH TANABE, OSAMU MURAOKA, XIAOMING WU, WEIJIA XIE: "First total synthesis of cyclic pentadepsipeptides Hikiamides A-C", TETRAHEDRON LETTERS, vol. 59, no. 30, 1 February 2018 (2018-02-01), pages 2876 - 2879, XP055889358, DOI: 10.1016/j.tetlet.2018.01.096
Attorney, Agent or Firm:
JEONG, Seong Jong (KR)
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