Title:
NOVEL BENFOTIAMINE CHOLINE SALT
Document Type and Number:
WIPO Patent Application WO/2024/049275
Kind Code:
A1
Abstract:
The present invention relates to a novel benfotiamine choline salt, a preparation method thereof, and a use thereof. A benfotiamine choline salt according to the present invention has excellent stability and significantly higher water solubility compared to conventional benfotiamine, thus exhibiting improved dissolution and bioavailability. In addition, a benfotiamine choline salt according to the present invention is effective to improve cognitive functions or to prevent or treat cranial nerve diseases, and thus it can be usefully applied as a pharmaceutical raw material or health functional food raw material.
Inventors:
YOO JI SEOK (KR)
LEE YONGNAM (KR)
LEE JONG HUN (KR)
BAEK JU YOUNG (KR)
KIM DAE HYEON (KR)
LEE YONGNAM (KR)
LEE JONG HUN (KR)
BAEK JU YOUNG (KR)
KIM DAE HYEON (KR)
Application Number:
PCT/KR2023/013101
Publication Date:
March 07, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
REXPHARMTECH CO LTD (KR)
International Classes:
C07F9/6512; A23L33/10; A61K31/675; A61P25/28
Foreign References:
| KR20170061493A | 2017-06-05 | |||
| US20200390768A1 | 2020-12-17 | |||
| US20210163515A1 | 2021-06-03 |
Other References:
GIBSON GARY E., LUCHSINGER JOSÉ A., CIRIO ROSANNA, CHEN HUANLIAN, FRANCHINO-ELDER JESSICA, HIRSCH JOSEPH A., BETTENDORFF LUCIEN, C: "Benfotiamine and Cognitive Decline in Alzheimer’s Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial", JOURNAL OF ALZHEIMER`S DISEASE, IOS PRESS, NL, vol. 78, no. 3, 24 November 2020 (2020-11-24), NL , pages 989 - 1010, XP093144036, ISSN: 1387-2877, DOI: 10.3233/JAD-200896
ZHANG HAICHUN, WANG JIE, CHEN ZHUO, PAN YUQIAN, LU ZHAOJUN, LIU ZHENGLIN: "An SVM-Based NAND Flash Endurance Prediction Method", MICROMACHINES, vol. 12, no. 7, pages 746, XP093144034, ISSN: 2072-666X, DOI: 10.3390/mi12070746
ZHANG HAICHUN, WANG JIE, CHEN ZHUO, PAN YUQIAN, LU ZHAOJUN, LIU ZHENGLIN: "An SVM-Based NAND Flash Endurance Prediction Method", MICROMACHINES, vol. 12, no. 7, pages 746, XP093144034, ISSN: 2072-666X, DOI: 10.3390/mi12070746
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
Download PDF: