Title:
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/088408
Kind Code:
A1
Abstract:
Disclosed are a nitrogen-containing heterocyclic compound, a pharmaceutically acceptable salt thereof, a preparation method therefor and the use thereof. Provided is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof. The compound of the present invention can be used as a positive allosteric modulator of a muscarinic receptor, and the compound of the present invention can treat M receptor-mediated (or M receptor-related) diseases.
Inventors:
CHEN DEHENG (CN)
JIA HAIFEI (CN)
SHEN HUAQIONG (CN)
ZHAO LELE (CN)
JIA HAIFEI (CN)
SHEN HUAQIONG (CN)
ZHAO LELE (CN)
Application Number:
PCT/CN2023/127298
Publication Date:
May 02, 2024
Filing Date:
October 27, 2023
Export Citation:
Assignee:
NEUSHEN THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
C07D487/04; A61K31/437; A61P25/00; A61P25/16; A61P25/18; A61P25/28; C07D471/04
Foreign References:
| CN109641898A | 2019-04-16 | |||
| CN114728964A | 2022-07-08 | |||
| CN110944998A | 2020-03-31 | |||
| GB2285977A | 1995-08-02 | |||
| CN106795141A | 2017-05-31 |
Other References:
DATABASE Registry 25 August 2022 (2022-08-25), ANONYMOUS: "Urea, N-[(3-fluorophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165581, Database accession no. 2812176-42-2
DATABASE Registry 4 August 2022 (2022-08-04), ANONYMOUS: "Urea, N-[(3-cyanophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165584, Database accession no. 2802996-77-4
DATABASE Registry 28 July 2022 (2022-07-28), ANONYMOUS: "Urea, N-[(2-fluorophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165589, Database accession no. 2798617-85-1
DATABASE Registry 28 July 2022 (2022-07-28), ANONYMOUS: "Urea, N-[(4-cyanophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165594, Database accession no. 2798617-83-9
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "Urea, N-methyl-N-(phenylmethyl)-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165595, Database accession no. 2470940-04-4
DATABASE Registry 3 May 2020 (2020-05-03), ANONYMOUS: " Urea, N-[(4-chlorophenyl)methyl]-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165596, Database accession no. 2415625-11-3
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-[1-(2-pyrazinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165598, Database accession no. 2415538-80-4
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165602, Database accession no. 2415525-59-4
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-(phenylmethyl)-N'-[1-[4-(trifluoromethyl)-2-pyridinyl]-3- azetidinyl]- (CA INDEX NAME)", XP093165615, Database accession no. 2415500-03-5
DATABASE Registry 20 November 2019 (2019-11-20), ANONYMOUS: "Urea, N-(phenylmethyl)-N'-(1-thieno[3,2-d]pyrimidin-4-yl-3-azetidinyl)- (CA INDEX NAME)", XP093165616, Database accession no. 2380192-84-5
DATABASE Registry 20 November 2019 (2019-11-20), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-(1-thieno[3,2-d]pyrimidin-4-yl-3- azetidinyl)- (CA INDEX NAME)", XP093165618, Database accession no. 2380184-37-0
DATABASE Registry 5 September 2022 (2022-09-05), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-[4- (hydroxymethyl)-3-methylphenyl]- (CA INDEX NAME)", XP093165625, Database accession no. 2818714-85-9
DATABASE Registry 29 August 2022 (2022-08-29), ANONYMOUS: " 1-Propanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-3- hydroxy-2-phenyl- (CA INDEX NAME)", XP093165627, Database accession no. 2814323-04-9
DATABASE Registry 29 August 2022 (2022-08-29), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(3-methoxyphenyl)- (CA INDEX NAME)", XP093165629, Database accession no. 2813977-27-2
DATABASE Registry 26 August 2022 (2022-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy-3- methoxyphenyl)- (CA INDEX NAME)", XP093165632, Database accession no. 2813059-75-3
DATABASE Registry 26 August 2022 (2022-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(3- methoxyphenyl)- (CA INDEX NAME)", XP093165636, Database accession no. 2813059-65-1
DATABASE Registry 23 August 2022 (2022-08-23), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(3- methoxyphenyl)- (CA INDEX NAME)", XP093165640, Database accession no. 2810696-61-6
DATABASE Registry 19 August 2022 (2022-08-19), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(4- methoxyphenyl)- (CA INDEX NAME)", XP093165642, Database accession no. 2807801-44-9
DATABASE Registry 19 August 2022 (2022-08-19), ANONYMOUS: "1-Propanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- (4-fluorophenyl)-3-hydroxy- (CA INDEX NAME)", XP093165646, Database accession no. 2807757-15-7
DATABASE Registry 17 August 2022 (2022-08-17), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(3- hydroxy-4-methoxyphenyl)- (CA INDEX NAME)", XP093165761, Database accession no. 2806650-86-0
DATABASE Registry 15 August 2022 (2022-08-15), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(4-methoxyphenyl)- (CA INDEX NAME)", XP093165763, Database accession no. 2804986-38-5
DATABASE Registry 14 August 2022 (2022-08-14), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-[2- (hydroxymethyl)phenyl]- (CA INDEX NAME)", XP093165767, Database accession no. 2804313-44-6
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(4- methoxyphenyl)- (CA INDEX NAME)", XP093165772, Database accession no. 2802038-02-2
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(4- hydroxy-3-methoxyphenyl)- (CA INDEX NAME)", XP093165773, Database accession no. 2801873-85-6
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(2-methoxyphenyl)- (CA INDEX NAME)", XP093165774, Database accession no. 2801807-43-0
DATABASE Registry 2 August 2022 (2022-08-02), ANONYMOUS: " 1-Butanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-phenyl- (CA INDEX NAME)", XP093165775, Database accession no. 2801424-08-6
DATABASE Registry 1 August 2022 (2022-08-01), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(2- hydroxyphenyl)-2-methoxy- (CA INDEX NAME)", XP093165784, Database accession no. 2800672-04-0
DATABASE Registry 1 August 2022 (2022-08-01), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-3-hydroxy-2- phenyl- (CA INDEX NAME)", XP093165862, Database accession no. 2800526-99-0
DATABASE Registry 31 July 2022 (2022-07-31), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(3-hydroxy-4- methoxyphenyl)- (CA INDEX NAME)", XP093165864, Database accession no. 2800202-92-8
DATABASE Registry 29 July 2022 (2022-07-29), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4- hydroxyphenyl)-2-methoxy- (CA INDEX NAME)", XP093165866, Database accession no. 2799304-46-2
DATABASE Registry 1 July 2022 (2022-07-01), ANONYMOUS: " Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(2,5- dimethoxyphenyl)- (CA INDEX NAME)", XP093165868, Database accession no. 2782389-26-6
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(2- pyridinyl)- (CA INDEX NAME)", XP093165874, Database accession no. 2471619-59-5
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "INDEX NAME NOT YET ASSIGNED", XP093165876, Database accession no. 2471594-48-4
DATABASE Registry 27 August 2020 (2020-08-27), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3-fluoro-4- hydroxyphenyl)- (CA INDEX NAME)", XP093165880, Database accession no. 2464185-68-8
DATABASE Registry 26 August 2020 (2020-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy-3- methoxyphenyl)- (CA INDEX NAM", XP093165883, Database accession no. 2461095-43-0
DATABASE Registry 29 July 2020 (2020-07-29), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3-hydroxy-4- methylphenyl)- (CA INDEX NAME)", XP093165884, Database accession no. 2451246-12-9
DATABASE Registry 26 July 2020 (2020-07-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4- hydroxyphenyl)- (CA INDEX NAME)", XP093165887, Database accession no. 2449735-46-8
DATABASE Registry 24 June 2020 (2020-06-24), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy- 3,5-dimethoxyphenyl)- (CA INDEX NAME)", XP093165890, Database accession no. 2433062-22-5
DATABASE Registry 23 June 2020 (2020-06-23), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3- hydroxyphenyl)- (CA INDEX NAME)", XP093165560, Database accession no. 2432638-20-3
DATABASE Registry 16 June 2020 (2020-06-16), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(2- hydroxyphenyl)- (CA INDEX NAME)", XP093165562, Database accession no. 2426565-19-5
DATABASE Registry 12 June 2020 (2020-06-12), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-3- pyridinyl)- (CA INDEX NAME)", XP093165565, Database accession no. 2423666-54-8
DATABASE Registry 20 December 2019 (2019-12-20), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-2- pyridinyl)- (CA INDEX NAME)", XP093165567, Database accession no. 2395215-97-9
DATABASE Registry 17 December 2019 (2019-12-17), ANONYMOUS: " Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-2- pyridinyl)- (CA INDEX NAME)", XP093165570, Database accession no. 2392834-49-8
DATABASE Registry 4 September 2019 (2019-09-04), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-[2- (hydroxymethyl)phenyl]- (CA INDEX NAME)", XP093165575, Database accession no. 2373600-92-9
DATABASE Registry 3 September 2019 (2019-09-03), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-3-hydroxy-2- phenyl- (CA INDEX NAME)", XP093165578, Database accession no. 2373032-85-8
DATABASE Registry 4 August 2022 (2022-08-04), ANONYMOUS: "Urea, N-[(3-cyanophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165584, Database accession no. 2802996-77-4
DATABASE Registry 28 July 2022 (2022-07-28), ANONYMOUS: "Urea, N-[(2-fluorophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165589, Database accession no. 2798617-85-1
DATABASE Registry 28 July 2022 (2022-07-28), ANONYMOUS: "Urea, N-[(4-cyanophenyl)methyl]-N-methyl-N'-(1-phenyl-3-azetidinyl)- (CA INDEX NAME)", XP093165594, Database accession no. 2798617-83-9
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "Urea, N-methyl-N-(phenylmethyl)-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165595, Database accession no. 2470940-04-4
DATABASE Registry 3 May 2020 (2020-05-03), ANONYMOUS: " Urea, N-[(4-chlorophenyl)methyl]-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165596, Database accession no. 2415625-11-3
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-[1-(2-pyrazinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165598, Database accession no. 2415538-80-4
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-[1-(2-pyridinyl)-3-azetidinyl]- (CA INDEX NAME)", XP093165602, Database accession no. 2415525-59-4
DATABASE Registry 1 May 2020 (2020-05-01), ANONYMOUS: "Urea, N-(phenylmethyl)-N'-[1-[4-(trifluoromethyl)-2-pyridinyl]-3- azetidinyl]- (CA INDEX NAME)", XP093165615, Database accession no. 2415500-03-5
DATABASE Registry 20 November 2019 (2019-11-20), ANONYMOUS: "Urea, N-(phenylmethyl)-N'-(1-thieno[3,2-d]pyrimidin-4-yl-3-azetidinyl)- (CA INDEX NAME)", XP093165616, Database accession no. 2380192-84-5
DATABASE Registry 20 November 2019 (2019-11-20), ANONYMOUS: "Urea, N-[(4-fluorophenyl)methyl]-N'-(1-thieno[3,2-d]pyrimidin-4-yl-3- azetidinyl)- (CA INDEX NAME)", XP093165618, Database accession no. 2380184-37-0
DATABASE Registry 5 September 2022 (2022-09-05), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-[4- (hydroxymethyl)-3-methylphenyl]- (CA INDEX NAME)", XP093165625, Database accession no. 2818714-85-9
DATABASE Registry 29 August 2022 (2022-08-29), ANONYMOUS: " 1-Propanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-3- hydroxy-2-phenyl- (CA INDEX NAME)", XP093165627, Database accession no. 2814323-04-9
DATABASE Registry 29 August 2022 (2022-08-29), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(3-methoxyphenyl)- (CA INDEX NAME)", XP093165629, Database accession no. 2813977-27-2
DATABASE Registry 26 August 2022 (2022-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy-3- methoxyphenyl)- (CA INDEX NAME)", XP093165632, Database accession no. 2813059-75-3
DATABASE Registry 26 August 2022 (2022-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(3- methoxyphenyl)- (CA INDEX NAME)", XP093165636, Database accession no. 2813059-65-1
DATABASE Registry 23 August 2022 (2022-08-23), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(3- methoxyphenyl)- (CA INDEX NAME)", XP093165640, Database accession no. 2810696-61-6
DATABASE Registry 19 August 2022 (2022-08-19), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(4- methoxyphenyl)- (CA INDEX NAME)", XP093165642, Database accession no. 2807801-44-9
DATABASE Registry 19 August 2022 (2022-08-19), ANONYMOUS: "1-Propanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- (4-fluorophenyl)-3-hydroxy- (CA INDEX NAME)", XP093165646, Database accession no. 2807757-15-7
DATABASE Registry 17 August 2022 (2022-08-17), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(3- hydroxy-4-methoxyphenyl)- (CA INDEX NAME)", XP093165761, Database accession no. 2806650-86-0
DATABASE Registry 15 August 2022 (2022-08-15), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(4-methoxyphenyl)- (CA INDEX NAME)", XP093165763, Database accession no. 2804986-38-5
DATABASE Registry 14 August 2022 (2022-08-14), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-[2- (hydroxymethyl)phenyl]- (CA INDEX NAME)", XP093165767, Database accession no. 2804313-44-6
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-hydroxy-2-(4- methoxyphenyl)- (CA INDEX NAME)", XP093165772, Database accession no. 2802038-02-2
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(4- hydroxy-3-methoxyphenyl)- (CA INDEX NAME)", XP093165773, Database accession no. 2801873-85-6
DATABASE Registry 3 August 2022 (2022-08-03), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-(2-methoxyphenyl)- (CA INDEX NAME)", XP093165774, Database accession no. 2801807-43-0
DATABASE Registry 2 August 2022 (2022-08-02), ANONYMOUS: " 1-Butanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2- hydroxy-2-phenyl- (CA INDEX NAME)", XP093165775, Database accession no. 2801424-08-6
DATABASE Registry 1 August 2022 (2022-08-01), ANONYMOUS: "Ethanone, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-(2- hydroxyphenyl)-2-methoxy- (CA INDEX NAME)", XP093165784, Database accession no. 2800672-04-0
DATABASE Registry 1 August 2022 (2022-08-01), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-3-hydroxy-2- phenyl- (CA INDEX NAME)", XP093165862, Database accession no. 2800526-99-0
DATABASE Registry 31 July 2022 (2022-07-31), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(3-hydroxy-4- methoxyphenyl)- (CA INDEX NAME)", XP093165864, Database accession no. 2800202-92-8
DATABASE Registry 29 July 2022 (2022-07-29), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4- hydroxyphenyl)-2-methoxy- (CA INDEX NAME)", XP093165866, Database accession no. 2799304-46-2
DATABASE Registry 1 July 2022 (2022-07-01), ANONYMOUS: " Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(2,5- dimethoxyphenyl)- (CA INDEX NAME)", XP093165868, Database accession no. 2782389-26-6
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(2- pyridinyl)- (CA INDEX NAME)", XP093165874, Database accession no. 2471619-59-5
DATABASE Registry 3 September 2020 (2020-09-03), ANONYMOUS: "INDEX NAME NOT YET ASSIGNED", XP093165876, Database accession no. 2471594-48-4
DATABASE Registry 27 August 2020 (2020-08-27), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3-fluoro-4- hydroxyphenyl)- (CA INDEX NAME)", XP093165880, Database accession no. 2464185-68-8
DATABASE Registry 26 August 2020 (2020-08-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy-3- methoxyphenyl)- (CA INDEX NAM", XP093165883, Database accession no. 2461095-43-0
DATABASE Registry 29 July 2020 (2020-07-29), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3-hydroxy-4- methylphenyl)- (CA INDEX NAME)", XP093165884, Database accession no. 2451246-12-9
DATABASE Registry 26 July 2020 (2020-07-26), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4- hydroxyphenyl)- (CA INDEX NAME)", XP093165887, Database accession no. 2449735-46-8
DATABASE Registry 24 June 2020 (2020-06-24), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(4-hydroxy- 3,5-dimethoxyphenyl)- (CA INDEX NAME)", XP093165890, Database accession no. 2433062-22-5
DATABASE Registry 23 June 2020 (2020-06-23), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(3- hydroxyphenyl)- (CA INDEX NAME)", XP093165560, Database accession no. 2432638-20-3
DATABASE Registry 16 June 2020 (2020-06-16), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(2- hydroxyphenyl)- (CA INDEX NAME)", XP093165562, Database accession no. 2426565-19-5
DATABASE Registry 12 June 2020 (2020-06-12), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-3- pyridinyl)- (CA INDEX NAME)", XP093165565, Database accession no. 2423666-54-8
DATABASE Registry 20 December 2019 (2019-12-20), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-2- pyridinyl)- (CA INDEX NAME)", XP093165567, Database accession no. 2395215-97-9
DATABASE Registry 17 December 2019 (2019-12-17), ANONYMOUS: " Ethanone, 1-(3,4-dihydro-6,8-dimethyl-2(1H)-isoquinolinyl)-2-(5-hydroxy-2- pyridinyl)- (CA INDEX NAME)", XP093165570, Database accession no. 2392834-49-8
DATABASE Registry 4 September 2019 (2019-09-04), ANONYMOUS: "Ethanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-2-[2- (hydroxymethyl)phenyl]- (CA INDEX NAME)", XP093165575, Database accession no. 2373600-92-9
DATABASE Registry 3 September 2019 (2019-09-03), ANONYMOUS: "1-Propanone, 1-(3,4-dihydro-5,7-dimethyl-2(1H)-isoquinolinyl)-3-hydroxy-2- phenyl- (CA INDEX NAME)", XP093165578, Database accession no. 2373032-85-8
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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