Title:
NEW INDUSTRIAL CRYSTALLISATION METHOD FOR CEFUROXIME SODIUM AND PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/201905
Kind Code:
A1
Abstract:
Disclosed is a new industrial crystallisation technique for cefuroxime sodium, wherein a supercritical fluid extraction technique is combined with conventional crystallization techniques to realize the recrystallization of cefuroxime sodium. Within the whole crystallization system, under the conditions of a specific temperature and pressure, the processes of extraction, adsorption, crystallization and drying are done so as to realize the recrystallization of cefuroxime sodium with the combined action of a supercritical fluid, a solvent, an extraction pool and a crystallizing pool. The present method has a high separation efficiency and few impurities, and greatly improves the quality of preparation products.
Inventors:
TAO LINGGANG (CN)
HAO HONGXUN (CN)
WANG JINGKANG (CN)
HAO HONGXUN (CN)
WANG JINGKANG (CN)
Application Number:
PCT/CN2015/095810
Publication Date:
December 22, 2016
Filing Date:
November 27, 2015
Export Citation:
Assignee:
HAINAN LINGKANG PHARMACEUTICAL (CN)
UNIV TIANJIN (CN)
UNIV TIANJIN (CN)
International Classes:
A61K9/14; C07D501/34; C07D501/12
Foreign References:
| CN101054386A | 2007-10-17 | |||
| US4581166A | 1986-04-08 |
Other References:
BIENKOWSKI, P.R. ET AL.: "Evaluation of Separation and Purification Processes in the Antibiotic Industry", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 18, 31 December 1988 (1988-12-31), pages 261 - 273, XP035176956
Attorney, Agent or Firm:
BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
北京康思博达知识产权代理事务所（普通合伙） (CN)
北京康思博达知识产权代理事务所（普通合伙） (CN)
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