Title:
NECTIN-4-TARGETED BICYCLIC PEPTIDE NUCLIDE LIGAND AND PROBE
Document Type and Number:
WIPO Patent Application WO/2023/098072
Kind Code:
A1
Abstract:
Provided are a Nectin-4-targeted bicyclic peptide nuclide ligand and probe. The ligand has a structure represented by formula I, where X is Lys or Arg; and R is a group represented by formula II, formula III, formula IV or formula V. The probe has high tumor uptake and a high uptake ratio of tumor to muscle, and has good clinical application prospects.
Inventors:
YANG XING (CN)
DUAN XIAOJIANG (CN)
ZHU HUA (CN)
ZHANG NING (CN)
YANG ZHI (CN)
ZHANG JIANHUA (CN)
ZHANG ZHUOCHEN (CN)
DUAN XIAOJIANG (CN)
ZHU HUA (CN)
ZHANG NING (CN)
YANG ZHI (CN)
ZHANG JIANHUA (CN)
ZHANG ZHUOCHEN (CN)
Application Number:
PCT/CN2022/103338
Publication Date:
June 08, 2023
Filing Date:
July 01, 2022
Export Citation:
Assignee:
UNIV PEKING FIRST HOSPITAL (CN)
International Classes:
C07K7/08; A61K38/00; C07C275/16; C07D257/02
Domestic Patent References:
| WO2021028686A1 | 2021-02-18 |
Foreign References:
| CN114133434A | 2022-03-04 | |||
| CN112566651A | 2021-03-26 | |||
| CN112062695A | 2020-12-11 | |||
| US20190184043A1 | 2019-06-20 |
Other References:
WEN KAI, HU JI, DENG XUE-SONG, ZHAO HAI-LONG, LUO TIAN-WEI, CHEN MENG-YI, XU LIN, QIN XIANG-YU, YU JING-JING, CUI HAI-PING: "Preliminary Evaluation of Prostate Cancer Molecular Probe 68Ga-DOTA-ANCP-PSMA", JOURNAL OF NUCLEAR AND RADIOCHEMISTRY, vol. 42, no. 4, 31 August 2020 (2020-08-31), pages 292 - 299, XP093068653
CHATTERJEE SUBHAJIT, SINHA SAPTARSHI, KUNDU CHANAKYA NATH: "Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 911, 1 November 2021 (2021-11-01), NL , pages 174516, XP093068652, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2021.174516
CHATTERJEE SUBHAJIT, SINHA SAPTARSHI, KUNDU CHANAKYA NATH: "Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 911, 1 November 2021 (2021-11-01), NL , pages 174516, XP093068652, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2021.174516
Attorney, Agent or Firm:
BEIJING SICHUANG DACHENG INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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