Title:
NANOPARTICLES COMPRISING DRUG DIMERS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/048453
Kind Code:
A1
Abstract:
The present invention relates to nanoparticles comprising a drug dimer, and a use thereof. In addition, the nanoparticles may further comprise fucoidan. The nanoparticles comprising an obeticholic acid dimer compound can be used for treating a liver disease. The nanoparticles comprising a drug dimer of the present invention can increase a drug content and enhance drug dispersibility. In addition, the nanoparticles have increased in targeting efficiency. Therefore, an effective pharmacological effect can be obtained by using a smaller amount of a drug, and thus commercial applicability is excellent.
Inventors:
HWANG DO WON (KR)
KI YOUNG WOOK (KR)
YOO DONGHYUCK (KR)
KIM SUNGHAN (KR)
KI YOUNG WOOK (KR)
YOO DONGHYUCK (KR)
KIM SUNGHAN (KR)
Application Number:
PCT/KR2022/014034
Publication Date:
March 30, 2023
Filing Date:
September 20, 2022
Export Citation:
Assignee:
THERABEST CO LTD (KR)
International Classes:
C07J41/00; A61K9/51; A61K31/575; A61P1/16; C07J31/00
Domestic Patent References:
| WO2021188480A1 | 2021-09-23 |
Foreign References:
| CN107674106A | 2018-02-09 | |||
| KR20030069991A | 2003-08-27 | |||
| CN106046094A | 2016-10-26 |
Other References:
HONG SERI, LEE YEONGJONG, SHIN HYEONBIN, KIM TAEEON, JUNG EUNKYEONG, LEE DONGWON: "Nanoassemblies of Disulfide-Bridged Bile Acid Dimers as Therapeutics Agents for Hepatic Ischemia/Reperfusion Injury", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 4, no. 4, 19 April 2021 (2021-04-19), US , pages 3145 - 3154, XP093054558, ISSN: 2576-6422, DOI: 10.1021/acsabm.0c01554
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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