Title:
MULTI-SPECIFIC BIOCONJUGATE LINKER AND SYNTHETIC METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/100696
Kind Code:
A1
Abstract:
Disclosed in the present application are a multi-specific bioconjugate linker and a synthetic method therefor, and specifically, a compound or a tautomer, a mesomer, a racemate, an enantiomer, or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. Also disclosed in the present application are a preparation method for the compound and use in tumor treatment.
Inventors:
CHEN PENG (CN)
LIN FENG (CN)
LIN JIAN (CN)
ZHANG HENG (CN)
LIN FENG (CN)
LIN JIAN (CN)
ZHANG HENG (CN)
Application Number:
PCT/CN2021/130337
Publication Date:
May 19, 2022
Filing Date:
November 12, 2021
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07D257/08; A61K31/395; A61K39/44; A61P35/00; C07D225/08; C07K16/46
Domestic Patent References:
| WO2020002765A1 | 2020-01-02 | |||
| WO2018079882A1 | 2018-05-03 |
Foreign References:
| CN111433188A | 2020-07-17 | |||
| CN110997010A | 2020-04-10 | |||
| CN108289964A | 2018-07-17 | |||
| CN108449940A | 2018-08-24 | |||
| CN107847605A | 2018-03-27 | |||
| CN106660967A | 2017-05-10 |
Other References:
MBOYI CLÈVE D., VIVIER DELPHINE, DAHER AHMAD, FLEURAT‐LESSARD PAUL, CATTEY HÉLÈNE, DEVILLERS CHARLES H., BERNHARD CLAIRE, DENAT FR: "Bridge‐Clamp Bis(tetrazine)s with [N] 8 π‐Stacking Interactions and Azido‐ s ‐Aryl Tetrazines: Two Classes of Doubly Clickable Tetrazines", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, vol. 59, no. 3, 13 January 2020 (2020-01-13), pages 1149 - 1154, XP055931410, ISSN: 1433-7851, DOI: 10.1002/anie.201911947
GOBBO PIERANGELO, ROMAGNOLI TOMMASO, BARBON STEPHANIE M., PRICE JACQUELYN T., KEIR JENNIFER, GILROY JOE B., WORKENTIN MARK S.: "Expanding the scope of strained-alkyne chemistry: a protection–deprotection strategy via the formation of a dicobalt–hexacarbonyl complex", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 51, no. 30, 1 January 2015 (2015-01-01), UK , pages 6647 - 6650, XP055930761, ISSN: 1359-7345, DOI: 10.1039/C5CC01522G
HOLSTEIN JOSEPHIN M., MUTTACH FABIAN, SCHIEFELBEIN STEPHAN H. H., RENTMEISTER ANDREA: "Dual 5′ Cap Labeling Based on Regioselective RNA Methyltransferases and Bioorthogonal Reactions", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 25, 2 May 2017 (2017-05-02), DE, pages 6165 - 6173, XP055860503, ISSN: 0947-6539, DOI: 10.1002/chem.201604816
MEGURO TOMOHIRO, SAKATA YUKI, MORITA TAKAMOTO, HOSOYA TAKAMITSU, YOSHIDA SUGURU: "Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S , S -dioxide moiety and two azido groups", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 34, 28 April 2020 (2020-04-28), UK , pages 4720 - 4723, XP055931409, ISSN: 1359-7345, DOI: 10.1039/D0CC01810D
TERASHIMA NORIKAZU, SAKATA YUKI, MEGURO TOMOHIRO, HOSOYA TAKAMITSU, YOSHIDA SUGURU: "Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 90, 12 November 2020 (2020-11-12), UK , pages 14003 - 14006, XP055931408, ISSN: 1359-7345, DOI: 10.1039/D0CC06551J
GOBBO PIERANGELO, ROMAGNOLI TOMMASO, BARBON STEPHANIE M., PRICE JACQUELYN T., KEIR JENNIFER, GILROY JOE B., WORKENTIN MARK S.: "Expanding the scope of strained-alkyne chemistry: a protection–deprotection strategy via the formation of a dicobalt–hexacarbonyl complex", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 51, no. 30, 1 January 2015 (2015-01-01), UK , pages 6647 - 6650, XP055930761, ISSN: 1359-7345, DOI: 10.1039/C5CC01522G
HOLSTEIN JOSEPHIN M., MUTTACH FABIAN, SCHIEFELBEIN STEPHAN H. H., RENTMEISTER ANDREA: "Dual 5′ Cap Labeling Based on Regioselective RNA Methyltransferases and Bioorthogonal Reactions", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 25, 2 May 2017 (2017-05-02), DE, pages 6165 - 6173, XP055860503, ISSN: 0947-6539, DOI: 10.1002/chem.201604816
MEGURO TOMOHIRO, SAKATA YUKI, MORITA TAKAMOTO, HOSOYA TAKAMITSU, YOSHIDA SUGURU: "Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S , S -dioxide moiety and two azido groups", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 34, 28 April 2020 (2020-04-28), UK , pages 4720 - 4723, XP055931409, ISSN: 1359-7345, DOI: 10.1039/D0CC01810D
TERASHIMA NORIKAZU, SAKATA YUKI, MEGURO TOMOHIRO, HOSOYA TAKAMITSU, YOSHIDA SUGURU: "Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 90, 12 November 2020 (2020-11-12), UK , pages 14003 - 14006, XP055931408, ISSN: 1359-7345, DOI: 10.1039/D0CC06551J
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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