MODIFIED FIBROIN

WIPO Patent Application WO/2024/034631

A1

The present invention is a modified fibroin that contains a domain sequence represented by formula 1: [(A)n motif-REP]m or formula 2: [(A)n motif-REP]m-(A)n motif and has a GQ motif content of 12.5% or less. (In formulae 1 and 2, (A)n motif represents an amino acid sequence consisting of 4-27 amino acid residues and, in (A) n motif, the total number of alanine residues, serine residues, threonine residues, and valine residues is 80% or more relative to the total number of amino acid residues. REP represents an amino acid sequence consisting of 10-200 amino acid residues. m represents an integer of 8-300. The plurality of (A) n motifs, etc., may be either the same or different amino acid sequences.)

NAKAMURA HIROYUKI (JP)
SATO CHIKAKO (JP)
ITO YUSUKE (JP)
NUMATA KEIJI (JP)
ARAKAWA KAZUHARU (JP)
KONO NOBUAKI (JP)

PCT/JP2023/029040

February 15, 2024

August 09, 2023

Click for automatic bibliography generation  

SPIBER INC (JP)
UNIV KYOTO (JP)
UNIV KEIO (JP)

C12N15/12; C07K14/435; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12N15/86; D01F4/02

MING XU , LEWIS R V: "Structure of a protein superfiber: Spider dragline silk", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 87, no. 18, 1 September 1990 (1990-09-01), pages 7120 - 7124, XP002269048, ISSN: 0027-8424, DOI: 10.1073/pnas.87.18.7120
HINMAN MICHAEL B, LEWIS RANDOLPH V: "Isolation of a Clone Encoding a Second Dragline Silk Fibroin - NEPHZLA CLAVZPES DRAGLINE SILK IS A TWO-PROTEIN FIBER", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 27, 25 September 1992 (1992-09-25), pages 19320 - 19324, XP093138166

SAEGUSA & PARTNERS (JP)

View/Download PDF      PDF Help

Previous Patent: IMAGE PROCESSING DEVICE, MODEL GENERATION DEVICE, SKIN STATE MEASUREMENT SYSTEM, IMAGE PROCESSING ME...

Next Patent: VAPOR CHAMBER, COOLING DEVICE, AND ELECTRONIC APPARATUS