MODIFIED COVALENTLY-LINKED PILI AND RECOMBINANT BACTERIA COMPRISING THE SAME - SHENZHEN INSTITUTE OF ADVANCED TECH CHINESE ACADEMY OF SCIENCES

Title:

MODIFIED COVALENTLY-LINKED PILI AND RECOMBINANT BACTERIA COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2024/092769

Kind Code:

A1

Abstract:

Provided is a fusion polypeptide comprising a carrier protein and a polypeptide of interest, wherein the polypeptide of interest is fused to a terminus of the carrier protein or inserted into the carrier protein, and wherein the carrier protein is a pilin of covalently- linked pili (CLP) from a microorganism. Also provided is a recombinant cell comprising a modified CLP comprising the fusion polypeptide, as well as the modified CLP.

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Inventors:

ZHONG CHAO (CN)
HUANG YUANYUAN (CN)

Application Number:

PCT/CN2022/130033

Publication Date:

May 10, 2024

Filing Date:

November 04, 2022

Export Citation:

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Assignee:

SHENZHEN INSTITUTE OF ADVANCED TECH CHINESE ACADEMY OF SCIENCES (CN)

International Classes:

C07K14/34; C07K19/00; C12N15/62

Attorney, Agent or Firm:

NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (Tower C Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District, Beijing 3, CN)

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