Title:
METHODS OF TREATING DISORDERS ASSOCIATED WITH EYA OVEREXPRESSION AND MUTATIONS
Document Type and Number:
WIPO Patent Application WO/2024/064721
Kind Code:
A3
Abstract:
The present disclosure is concerned with methods of treating disorders associated with overexpression of an eyes absent (EYA) protein such as, for example, vascular disease, a fibrosis-related disorder, hearing loss, and a metabolic disease using quinazoline-2,4- diamines. Also disclosed are methods of treating cancer that comprises a tumor that overexpresses at least one eyes absent (EYA) protein (e.g, breast cancer, cervical cancer, ovarian cancer, liver cancer, pancreatic cancer, pediatric cancers). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Inventors:
MCHARDY STANTON (US)
DRAY ELOISE (US)
DRAY ELOISE (US)
Application Number:
PCT/US2023/074639
Publication Date:
May 02, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
UNIV TEXAS (US)
MCHARDY STANTON F (US)
MCHARDY STANTON F (US)
International Classes:
A61K31/33; A61K31/395; A61K31/40; A61K31/517; A61P3/00; A61P7/00; A61P35/00; C07D239/94
Attorney, Agent or Firm:
SHORTELL, D., Brian et al. (US)
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