Title:
METHOD AND SYSTEM FOR EVALUATING MOLECULAR DIFFUSION
Document Type and Number:
WIPO Patent Application WO/2023/079677
Kind Code:
A1
Abstract:
In a step S101, a solution of a dissolved target molecule (tracer molecule) is introduced into a flow path. The flow path comprises: a measurement region employing a surface plasmon resonance method, and a hydrogel layer disposed in the course of the measurement region. In a step S102 (measurement step), the solution introduced into the flow path is transported and the following are obtained: a first measurement effect due to a surface plasmon resonance method at a location in the measurement region where the hydrogel layer is not formed, and a second measurement effect due to a surface plasmon resonance method at a location in the measurement region where the hydrogel layer is formed. In a step S103 (evaluation step), the diffusion rate of the molecule in the hydrogel is evaluated by comparing the first measurement effect with the second measurement effect.
Inventors:
MURAI TOMOMI (JP)
INOUE SUZUYO (JP)
TANAKA AYA (JP)
TAKAHASHI RIKU (JP)
SEYAMA MICHIKO (JP)
INOUE SUZUYO (JP)
TANAKA AYA (JP)
TAKAHASHI RIKU (JP)
SEYAMA MICHIKO (JP)
Application Number:
PCT/JP2021/040751
Publication Date:
May 11, 2023
Filing Date:
November 05, 2021
Export Citation:
Assignee:
NIPPON TELEGRAPH & TELEPHONE (JP)
International Classes:
G01N13/00; G01N21/41
Domestic Patent References:
| WO2008093412A1 | 2008-08-07 |
Foreign References:
| JP2019512006A | 2019-05-09 | |||
| JP2007093300A | 2007-04-12 | |||
| CN203881647U | 2014-10-15 |
Other References:
HAGEL VALENTIN, HARASZTI TAMÁS, BOEHM HEIKE: "Diffusion and interaction in PEG-DA hydrogels", BIOINTERHASES, AMERICAN INSTITUTE OF PHYSICS, US, vol. 8, no. 1, 1 December 2013 (2013-12-01), US , pages 36, XP093064158, ISSN: 1934-8630, DOI: 10.1186/1559-4106-8-36
JOOSTEN JACQUES G. H., GELADÉ ERIK T. F., PUSEY PETER N.: "Dynamic light scattering by nonergodic media: Brownian particles trapped in polyacrylamide gels", PHYSICAL REVIEW A (ATOMIC, MOLECULAR, AND OPTICAL PHYSICS), AMERICAN PHYSICAL SOCIETY, USA, vol. 42, no. 4, 1 August 1990 (1990-08-01), USA , pages 2161 - 2175, XP093064162, ISSN: 1050-2947, DOI: 10.1103/PhysRevA.42.2161
MATSUKAWA SHINGO, ANDO ISAO: "A Study of Self-Diffusion of Molecules in Polymer Gel by Pulsed-Gradient Spin−Echo 1 H NMR", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 22, 1 January 1996 (1996-01-01), US , pages 7136 - 7140, XP093064167, ISSN: 0024-9297, DOI: 10.1021/ma960426r
JOOSTEN JACQUES G. H., GELADÉ ERIK T. F., PUSEY PETER N.: "Dynamic light scattering by nonergodic media: Brownian particles trapped in polyacrylamide gels", PHYSICAL REVIEW A (ATOMIC, MOLECULAR, AND OPTICAL PHYSICS), AMERICAN PHYSICAL SOCIETY, USA, vol. 42, no. 4, 1 August 1990 (1990-08-01), USA , pages 2161 - 2175, XP093064162, ISSN: 1050-2947, DOI: 10.1103/PhysRevA.42.2161
MATSUKAWA SHINGO, ANDO ISAO: "A Study of Self-Diffusion of Molecules in Polymer Gel by Pulsed-Gradient Spin−Echo 1 H NMR", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 22, 1 January 1996 (1996-01-01), US , pages 7136 - 7140, XP093064167, ISSN: 0024-9297, DOI: 10.1021/ma960426r
Attorney, Agent or Firm:
YAMAKAWA, Shigeki et al. (JP)
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