METHOD FOR SYNTHESIZING CARBON ISOTOPE-LABELED PYRUVIC ACID

WIPO Patent Application WO/2023/197522

A1

The present invention relates to the technical field of isotope-labeled drug synthesis, and specifically disclosed is a method for synthesizing a carbon isotope-labeled pyruvic acid, which method has few synthetic reaction steps, a high synthesis efficiency, a low cost, and a simple product extraction. The method comprises the following steps: S1, adding an isopropenyl Grignard reagent to a reaction container, and cooling to a pre-set temperature; S2, proportionally adding carbon isotope-labeled carbon dioxide into the reaction container and reacting for a pre-set time; S3, adding an acid into the reacted system, adjusting the temperature to a pre-set temperature, and performing a quenching reaction; S4, performing an ozonation reaction on the reaction product of the carbon dioxide and the isopropenyl Grignard reagent after the quenching reaction; S5, adding a reducing agent to reduce the product in the step S4; and S6, removing the impurity in the reduced product to obtain the carbon isotope-labeled pyruvic acid.

QING JING (CN)
JIA XUELEI (CN)
CHEN KAI (CN)
LI GUOWEI (CN)
HAN QUANSHENG (CN)
DAI DESHENG (CN)

PCT/CN2022/118953

October 19, 2023

September 15, 2022

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SHENZHEN ZHONGHE HEADWAY BIO SCI & TECH CO LTD (CN)

C07C51/373; C01B32/50; C07C51/15; C07C51/42; C07C51/48; C07C51/487; C07C59/19

WO2008011033A2

2008-01-24

CN101522604A	2009-09-02
US20080161593A1	2008-07-03
CN109096092A	2018-12-28
JPH0358954A	1991-03-14
US20060178534A1	2006-08-10
CN109096092A	2018-12-28

SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (CN)

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