Title:
A METHOD FOR THE SYNTHESIS AND PURIFICATION OF A NUCLEOTIDE AND/OR A NUCLEOSIDE, A MODIFIED NUCLEOTIDE AND/OR A NUCLEOSIDE, A DNA MOLECULE CONTAINING A SINGLE- OR DOUBLE-STRANDED OLIGONUCLEOTIDE CHAIN, AN OLIGONUCLEOTIDE LIBRARY, USE OF THE OLIGONUCLEOTIDE LIBRARY
Document Type and Number:
WIPO Patent Application WO/2024/049312
Kind Code:
A3
Abstract:
The first object of the invention is a method for the synthesis and purification of a nucleotide and/or a nucleoside. The second object of the invention is a modified nucleoside and/or a nucleotide, being a mono-, di- or triphosphate, containing as the nitrogenous base a cytosine or uracil derivative which, in the 5' position of the heterocyclic ring has a 1,2,3-triazole group or an alkane or an alkyne chain. The third object of the invention is a DNA molecule containing a single- or double-stranded oligonucleotide chain. The fourth object of the invention is a oligonucleotide library having in the sequence a region with any sequence at least 10 nucleotides in length and two regions flanking it with fixed sequences at least 10 nucleotides in length or without the flanking regions. A further object of the invention is the use of the oligonucleotide library for the preparation of aptamers using SELEX and derived technologies.
Inventors:
SOK-GROCHOWSKA AGNIESZKA (PL)
PUCHAŁA MAGDA JOANNA (PL)
KUCHARSKA BARBARA (PL)
JAKIMOWICZ PIOTR (PL)
CZARNECKA MONIKA (PL)
PUCHAŁA MAGDA JOANNA (PL)
KUCHARSKA BARBARA (PL)
JAKIMOWICZ PIOTR (PL)
CZARNECKA MONIKA (PL)
Application Number:
PCT/PL2023/050071
Publication Date:
May 02, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
PURE BIOLOGICS SPOLKA AKCYJNA (PL)
International Classes:
C07H1/00; C07H1/06; C07H19/073; C07H19/10; C07H21/04; C12N15/10; C12N15/115; C40B40/06
Foreign References:
| US10450673B2 | 2019-10-22 |
Attorney, Agent or Firm:
ŻYGADŁO, Krystian (PL)
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