Title:
METHOD FOR SELECTING SUBJECT-DERIVED NEOANTIGEN
Document Type and Number:
WIPO Patent Application WO/2024/034622
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a means for selecting a subject-derived neoantigen. The above problem is solved by providing, for example, a method for selecting a subject-derived neoantigen, said method comprising: a step for acquiring sequence data of a cancer cell and a normal cell derived from a subject; a step for identifying a gene that has a gene mutation specific to the cancer cell; and a step for identifying, from a major histocompatibility complex (MHC) presenting peptide database, a peptide based on a wild-type gene corresponding to the gene that has the gene mutation specific to the cancer cell, wherein the gene mutation is a missence mutation, and the peptide based on the wild-type gene corresponding to the gene that has the gene mutation has a wild-type amino acid corresponding to the position of an amino acid mutation caused by the gene mutation.
Inventors:
KANESEKI TAKAYUKI (JP)
TOKITA SERINA (JP)
TORIGOE TOSHIHIKO (JP)
TOKITA SERINA (JP)
TORIGOE TOSHIHIKO (JP)
Application Number:
PCT/JP2023/029006
Publication Date:
February 15, 2024
Filing Date:
August 08, 2023
Export Citation:
Assignee:
UNIV SAPPORO MEDICAL (JP)
International Classes:
C12N15/11; C07K4/12; C07K14/435; C12M1/00; C12Q1/6869
Domestic Patent References:
| WO2017159686A1 | 2017-09-21 |
Foreign References:
| JP2018520637A | 2018-08-02 | |||
| JP2022524328A | 2022-05-02 |
Other References:
LI YUYU, WANG GUANGZHI, TAN XIAOXIU, OUYANG JIAN, ZHANG MENGHUAN, SONG XIAOFENG, LIU QI, LENG QIBIN, CHEN LANMING, XIE LU: "ProGeo-neo: a customized proteogenomic workflow for neoantigen prediction and selection", BMC MEDICAL GENOMICS, BIOMED CENTRAL LTD, LONDON UK, vol. 13, no. S5, 11 June 2019 (2019-06-11), London UK , pages 52, XP093137232, ISSN: 1755-8794, DOI: 10.1186/s12920-020-0683-4
LIU CHUNYU, ZHANG YU, JIAN XINGXING, TAN XIAOXIU, LU MANMAN, OUYANG JIAN, LIU ZHENHAO, LI YUYU, XU LINFENG, CHEN LANMING, LIN YONG: "ProGeo-Neo v2.0: A One-Stop Software for Neoantigen Prediction and Filtering Based on the Proteogenomics Strategy", GENES, MDPI AG, US, vol. 13, no. 5, 28 April 2022 (2022-04-28), US , pages 783, XP093137238, ISSN: 2073-4425, DOI: 10.3390/genes13050783
GOPANENKO ALEXANDER V., KOSOBOKOVA EKATERINA N., KOSORUKOV VYACHESLAV S.: "Main Strategies for the Identification of Neoantigens", CANCERS, vol. 12, no. 10, 7 October 2020 (2020-10-07), pages 2879, XP055915967, DOI: 10.3390/cancers12102879
LIU CHUNYU, ZHANG YU, JIAN XINGXING, TAN XIAOXIU, LU MANMAN, OUYANG JIAN, LIU ZHENHAO, LI YUYU, XU LINFENG, CHEN LANMING, LIN YONG: "ProGeo-Neo v2.0: A One-Stop Software for Neoantigen Prediction and Filtering Based on the Proteogenomics Strategy", GENES, MDPI AG, US, vol. 13, no. 5, 28 April 2022 (2022-04-28), US , pages 783, XP093137238, ISSN: 2073-4425, DOI: 10.3390/genes13050783
GOPANENKO ALEXANDER V., KOSOBOKOVA EKATERINA N., KOSORUKOV VYACHESLAV S.: "Main Strategies for the Identification of Neoantigens", CANCERS, vol. 12, no. 10, 7 October 2020 (2020-10-07), pages 2879, XP055915967, DOI: 10.3390/cancers12102879
Attorney, Agent or Firm:
KUZUWA & PARTNERS, P.C. (JP)
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