Title:
METHOD FOR RATIONALLY CREATING PEPTOID INHIBITING PROTEIN INTERACTION
Document Type and Number:
WIPO Patent Application WO/2021/010316
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an N-substituted amino acid-containing peptide and a method for producing a protein binding factor using the peptide. More specifically, the present invention pertains to a peptide containing at least one residue of an N-substituted amino acid wherein the N-substituent is not a methyl group. The present invention also pertains to a method for synthesizing the aforesaid peptide that interacts with a protein, said method comprising acquiring the three-dimensional structure data of the protein, identifying an interaction region depending on the three-dimensional structure data, designing the peptide capable of binding to the interaction region, and then synthesizing the peptide thus designed.
Inventors:
SANDO SHINSUKE (JP)
MORIMOTO JUMPEI (JP)
FUKUDA YASUHIRO (JP)
WATANABE TAKUMU (JP)
MORIMOTO JUMPEI (JP)
FUKUDA YASUHIRO (JP)
WATANABE TAKUMU (JP)
Application Number:
PCT/JP2020/027010
Publication Date:
January 21, 2021
Filing Date:
July 10, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07K1/06; C07K2/00
Domestic Patent References:
| WO2018191411A1 | 2018-10-18 |
Foreign References:
| JP2019512541A | 2019-05-16 | |||
| JP2003510672A | 2003-03-18 |
Other References:
MORIMOTO, JUMPEI ET AL.: "Solid-Phase Synthesis of beta-Peptoids with Chiral Backbone Substituents Using Reductive Amination", ORGANIC LETTERS, vol. 19, 2017, pages 5912 - 5915, XP055788725
SANDO, SHINSUKE ET AL.: "Precise design of medium-sized molecules that specifically bind and inhibit/activate target", ABSTRACTS OF STRUCTURAL ACTIVITY FORUM 2019, 7 June 2019 (2019-06-07), pages 15 - 19
MORIMOTO, JUMPEI ET AL.: "A Peptoid with Extended Shape in Water", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 141, 12 August 2019 (2019-08-12), pages 14612 - 14623, XP055788732
FUKUDA, YASUHIRO ET AL.: "Conformational Studies of 01igo(N-substituted alanines) by X-ray Crystallographic Analysis", PEPTIDE SCIENCE 2018, vol. 2018, no. 55, 3 December 2018 (2018-12-03), pages 83
MORIMOTO, JUMPEI ET AL.: "Oligo(N-substituted alanines) as a Peptoid with Defined Shape in Water: Synthesis and Conformational Studies", PEPTIDE SCEINECE 2018, vol. 2018, no. 55, 3 December 2018 (2018-12-03), pages 92
SANDO, SHINSUKE ET AL.: "Precise design of medium-sized molecules that specifically bind and inhibit/activate target", ABSTRACTS OF STRUCTURAL ACTIVITY FORUM 2019, 7 June 2019 (2019-06-07), pages 15 - 19
MORIMOTO, JUMPEI ET AL.: "A Peptoid with Extended Shape in Water", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 141, 12 August 2019 (2019-08-12), pages 14612 - 14623, XP055788732
FUKUDA, YASUHIRO ET AL.: "Conformational Studies of 01igo(N-substituted alanines) by X-ray Crystallographic Analysis", PEPTIDE SCIENCE 2018, vol. 2018, no. 55, 3 December 2018 (2018-12-03), pages 83
MORIMOTO, JUMPEI ET AL.: "Oligo(N-substituted alanines) as a Peptoid with Defined Shape in Water: Synthesis and Conformational Studies", PEPTIDE SCEINECE 2018, vol. 2018, no. 55, 3 December 2018 (2018-12-03), pages 92
Attorney, Agent or Firm:
OKUHARA Koji et al. (JP)
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