Title:
METHOD FOR PURIFYING PROGESTERONE
Document Type and Number:
WIPO Patent Application WO/2021/238312
Kind Code:
A1
Abstract:
Disclosed is a method for purifying progesterone, belonging to the technical field of preparation and processing of steroid hormone medicaments. In the method, aldehyde impurities in crude progesterone are used to react with a sulfur-containing nucleophile reagent to generate highly polar hydroxysulfonates to achieve solubility difference with progesterone, then add water for precipitation, perform filtration, and the filter cake is washed with water and dried, so as to obtain highly pure progesterone having a content higher than 99.5% and the total content of impurity aldehydes lower than 0.2%. The purification method of the present invention avoids the technical bottleneck of progesterone purification in the prior art. Raw materials of reagents used in the reaction process are cheap and easily available. The purification process is simple and convenient to operate, has low requirements on equipment, and has low costs. The purification process is mild and safe, the conditions are easy to control, and the product purification recovery rate is high. The reagents used have low environmental pollution, and particularly, chromium-containing high-pollutive reagents are not used. The purification method satisfy the industry development trend of green chemistry, and have good economic and social benefits.
Inventors:
SHAO ZHENPING (CN)
WANG RONG (CN)
WANG BINGQIAN (CN)
WANG HONGFU (CN)
HUANG CHENGCHENG (CN)
LEI LINGZHI (CN)
WANG YOUFU (CN)
WANG RONG (CN)
WANG BINGQIAN (CN)
WANG HONGFU (CN)
HUANG CHENGCHENG (CN)
LEI LINGZHI (CN)
WANG YOUFU (CN)
Application Number:
PCT/CN2021/077911
Publication Date:
December 02, 2021
Filing Date:
February 25, 2021
Export Citation:
Assignee:
ZHEJIANG SHENZHOU PHARMACEUTICAL COMPANY LTD (CN)
International Classes:
C07J7/00
Foreign References:
| CN112390841A | 2021-02-23 | |||
| CN112062801A | 2020-12-11 | |||
| CN112110971A | 2020-12-22 | |||
| CN112250727A | 2021-01-22 | |||
| CN110563790A | 2019-12-13 | |||
| CN110204585A | 2019-09-06 |
Other References:
HOU HAIBO, YANQING YANG, JIANXIONG ZHENG: "Study on the Purification Techniques of Mother Liquid of Progesterone", GUANGDONG CHEMICAL INDUSTRY, vol. 46, no. 2, 28 February 2019 (2019-02-28), pages 104 - 105, XP055873290
TROST BARRY M., TAMARU YOSHINAO: "New synthetic reactions. Oxidative decarboxylation of .alpha.-methylthiocarboxylic acids, new approach to acyl anion and ketene synthons", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 99, no. 9, 1 April 1977 (1977-04-01), pages 3101 - 3113, XP055871868, ISSN: 0002-7863, DOI: 10.1021/ja00451a041
"Sodium Formaldehyde Bisulfite", BAIDU BAIKE, CN, pages 1 - 3, XP009532335, Retrieved from the Internet
TROST BARRY M., TAMARU YOSHINAO: "New synthetic reactions. Oxidative decarboxylation of .alpha.-methylthiocarboxylic acids, new approach to acyl anion and ketene synthons", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 99, no. 9, 1 April 1977 (1977-04-01), pages 3101 - 3113, XP055871868, ISSN: 0002-7863, DOI: 10.1021/ja00451a041
"Sodium Formaldehyde Bisulfite", BAIDU BAIKE, CN, pages 1 - 3, XP009532335, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING HOFUWIN INTELLECTUAL PROPERTY LAW FIRM (CN)
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