METHOD FOR PRODUCING RADIOACTIVE ZIRCONIUM COMPLEX

WIPO Patent Application WO/2022/085570

A9

The present invention pertains to a method that is for producing a radioactive zirconium labelled complex and that can achieve a high labelling rate in a reaction between a ligand compound and radioactive zirconium ions. The production method according to the present invention comprises a step for causing a reaction between a ligand compound and radioactive zirconium ions in a reaction solution containing water to cause coordination of the radioactive zirconium ions. Said step is performed in a state where the pH of the reaction solution is in an acidic range. The reaction solution does not contain an organic solvent but contains, apart from the ligand compound, a water-soluble organic compound that has, in the structure, one or two sulfo groups or carboxy groups.

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TAKEMORI HIDEAKI (JP)
ICHIKAWA HIROAKI (JP)
KAWATANI MINORU (JP)
IZAWA AKIHIRO (JP)
IMAI TOMOYUKI (JP)

PCT/JP2021/038135

August 31, 2023

October 14, 2021

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NIHON MEDIPHYSICS CO LTD (JP)

C07D257/02; A61K47/60; A61K47/62; A61K47/64; A61K47/68; A61K51/04

SHOWA INTERNATIONAL PATENT FIRM (JP)

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