Title:
METHOD FOR PREPARING 9Β,10Α-PREGNANE-4,6-DIENE-3,20-DIONE
Document Type and Number:
WIPO Patent Application WO/2016/154772
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing 9β,10α-pregnane-4,6-diene-3,20-dione. The preparation method uses 9β,10α-pregnane-5,7-diene-3,20-dione diethyl diacetal (compound A) as a raw material, which is deprotected under acidic conditions to give 9β,10α-pregnane-4,7-diene-3,20-dione (compound B), which then undergoes rearrangement under alkaline conditions to give 9β,10α-pregnane-4,6-diene-3,20-dione (compound C). The method of the present invention is simple, environmentally-friendly and has a very high yield.
Inventors:
DONG JUNGUO (CN)
WU ZHIPING (CN)
CHEN JIGU (CN)
WU ZHIPING (CN)
CHEN JIGU (CN)
Application Number:
PCT/CN2015/000231
Publication Date:
October 06, 2016
Filing Date:
April 02, 2015
Export Citation:
Assignee:
TAIZHOU HISOUND PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J75/00; C07J7/00
Domestic Patent References:
| WO2013078575A8 | 2013-07-18 |
Foreign References:
| CN104237417A | 2014-12-24 | |||
| US3364205A | 1968-01-16 |
Other References:
ANTONUCCI, ROSE.: "? 5,7- Steroids . XIII. Steroidal Cyclic Ketals. II The preparation of ? 4, 7-Pregnadiene-3, 20-dione and ? 4, 7-Pregnadiene-21-ol-3, 20-dione-acetate", JOURNAL OF ORGANIC CHEMISTRY, vol. 17, 31 December 1952 (1952-12-31), pages 1369 - 1374, XP055319617, ISSN: 0022-3263
Attorney, Agent or Firm:
BEIJING ZHONGYUAN HUAHE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
北京中原华和知识产权代理有限责任公司 (CN)
北京中原华和知识产权代理有限责任公司 (CN)
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