Title:
METHOD OF PREPARING METHOXY POLY(ETHYLENE GLYCOL)-B-POLY(L-LACTIDE) BLOCK COPOLYMER
Document Type and Number:
WIPO Patent Application WO/2023/208121
Kind Code:
A1
Abstract:
A method of preparing a methoxy poly(ethylene glycol)-b-poly(L-lactide) (mPEG-PLLA) block copolymer is disclosed. During preparation of lactide, a mixture of antimony trioxide and phosphoric acid is used as a catalyst; at the same time, by also using a deep hydrolysis process, the optical purity of the lactide is increased; while the lactide and methoxy poly(ethylene glycol) are subjected to ring-opening polymerization to generate an mPEG-PLLA block copolymer, a solution polymerization reaction system is combined with a composite aluminum catalyst, and with colloid hierarchical purification and other processes to accurately control the molecular weight of the finished mPEG-PLLA block copolymer product. The invention allows for an increased finished product yield, as well as elimination of the toxic side effects on the human body that the high levels of tin residues in current mPEG-PLLA block copolymer processes can cause.
Inventors:
LI RUIZHI (CN)
ZHANG KUN (CN)
XU KAI (CN)
SONG DAWEI (CN)
ZHANG KUN (CN)
XU KAI (CN)
SONG DAWEI (CN)
Application Number:
PCT/CN2023/091215
Publication Date:
November 02, 2023
Filing Date:
April 27, 2023
Export Citation:
Assignee:
IMEIK TECH DEVELOPMENT CO LTD (CN)
International Classes:
C08G63/664; C07D319/12; C08G63/84
Foreign References:
| CN111777750A | 2020-10-16 | |||
| CN111978520A | 2020-11-24 | |||
| CN101555243A | 2009-10-14 | |||
| CN110128397A | 2019-08-16 | |||
| CN102300904A | 2011-12-28 |
Other References:
DENG X. M., ET AL.: "STUDIES OF THE BLOCK COPOLYMERIZATION OF D,L-LACTIDE AND POLY(ETHYLENE GLYCOL) WITH ALUMINUM COMPLEX CATALYST.", JOURNAL OF APPLIED POLYMER SCIENCE, JOHN WILEY & SONS, INC., US, vol. 55, no. 08, 22 February 1995 (1995-02-22), US , pages 1193 - 1196, XP000516803, ISSN: 0021-8995, DOI: 10.1002/app.1995.070550806
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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