Title:
METHOD FOR PREPARING COMPOUND HAVING BIFUNCTIONAL GROUP
Document Type and Number:
WIPO Patent Application WO/2018/137260
Kind Code:
A1
Abstract:
Disclosed in the present application is a method for preparing a compound I, which is characterized in being prepared and obtained by reacting starting materials which comprise a compound II, which contains a carbon-carbon double bond, and a compound III, which contains a nitrile group, in the presence of a catalyst and a free radical initiator. The method uses a copper-based catalyst and uses a nitrile-containing compound as a bifunctional reagent to achieve an olefin compound undergoing an amination reaction and cyanomethylation simultaneously for the first time to prepare and obtain a core skeleton of a γ-aminobutyric acid derivative.
More Like This:
Inventors:
BAO HONGLI (CN)
ZHU NENGBO (CN)
GE LIANG (CN)
FENG WEIWEI (CN)
ZHU NENGBO (CN)
GE LIANG (CN)
FENG WEIWEI (CN)
Application Number:
PCT/CN2017/073325
Publication Date:
August 02, 2018
Filing Date:
February 13, 2017
Export Citation:
Assignee:
FUJIAN INST RES STR MATTER CAS (CN)
International Classes:
C07C255/44; C07B43/06; C07C253/30; C07J7/00
Other References:
KENSUKE, K. ET AL.: "Ritter-type Amination of C-H Bonds at Tertiary Carbon Centers Using Iodic Acid as an Oxidant", CHEMICAL COMMUNICATIONS, vol. 52, no. 89, 22 September 2016 (2016-09-22), pages 13049 - 13182, XP055526975
WADE, P.A. ET AL.: "Synthesis and Conjugate Addition Reactions of N-(b-nitroalkyl)amides", TETRAHEDRON LETTERS, vol. 56, no. 48, 19 October 2015 (2015-10-19), pages 6722 - 6725, XP055526977
WANG, JIANFENG ET AL.: "Aminobutyric Acid Physiological Function and Preparation Methods Were Reviewed", SHANDONG CHEMICAL INDUSTRY, vol. 42, 31 December 2013 (2013-12-31), pages 51 - 52
WADE, P.A. ET AL.: "Synthesis and Conjugate Addition Reactions of N-(b-nitroalkyl)amides", TETRAHEDRON LETTERS, vol. 56, no. 48, 19 October 2015 (2015-10-19), pages 6722 - 6725, XP055526977
WANG, JIANFENG ET AL.: "Aminobutyric Acid Physiological Function and Preparation Methods Were Reviewed", SHANDONG CHEMICAL INDUSTRY, vol. 42, 31 December 2013 (2013-12-31), pages 51 - 52
Attorney, Agent or Firm:
PERIODIC LAW FIRM (CN)
Download PDF:
Previous Patent: BATTERY MODULE
Next Patent: METHOD AND APPARATUS FOR RESOURCE ALLOCATION SIGNALING IN A JOINT TRANSMISSION CELLULAR COMMUNICATIO...
Next Patent: METHOD AND APPARATUS FOR RESOURCE ALLOCATION SIGNALING IN A JOINT TRANSMISSION CELLULAR COMMUNICATIO...