Title:
METHOD FOR PREPARING ATORVASTATIN CALCIUM
Document Type and Number:
WIPO Patent Application WO/2024/036812
Kind Code:
A1
Abstract:
The present invention relates to the technical field of organic synthesis, in particular to a method for preparing atorvastatin calcium. The method comprises: using 2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)acetonitrile as a raw material, reacting same with 2,2-dimethoxypropane to add a protecting group, then performing hydrogenation reduction, docking same to the main nucleus, and finally hydrolyzing same into a salt to prepare the atorvastatin calcium. Compared with an existing method, the preparation method of the present invention has a mild reaction condition, convenient operation, high yield and purity and low cost, and is suitable for mass industrial production.
Inventors:
JIANG TAO (CN)
Application Number:
PCT/CN2022/135696
Publication Date:
February 22, 2024
Filing Date:
November 30, 2022
Export Citation:
Assignee:
CHONGQING PUYOU BIOPHARMA CO LTD (CN)
International Classes:
C07D309/16; C07D207/34
Domestic Patent References:
| WO2007034012A2 | 2007-03-29 |
Foreign References:
| US5298627A | 1994-03-29 | |||
| US20050153407A1 | 2005-07-14 | |||
| CN1780826A | 2006-05-31 | |||
| US20060199855A1 | 2006-09-07 |
Attorney, Agent or Firm:
BEIJING TIANTONG ZHICHUANG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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