Title:
METHOD FOR PREPARING ACETOACETAMIDE-N-SULFONIC ACID TRIETHYLAMINE SALT
Document Type and Number:
WIPO Patent Application WO/2022/246870
Kind Code:
A1
Abstract:
A method for preparing an acetoacetamide-N-sulfonic acid triethylamine salt, the method comprising: an amination reaction step, involving: dissolving sulfamic acid in first dichloromethane to obtain a first reaction solution; dissolving triethylamine in second dichloromethane to obtain a second reaction solution, and adding the second reaction solution into the first reaction solution for an amination reaction to form an ammonium sulfamate solution; and an acylation reaction step, involving: dissolving diketene in third dichloromethane to prepare a third reaction solution; filling a fixed bed reactor with a solid heteropolyacid catalyst, sequentially introducing the ammonium sulfamate solution and the third reaction solution into the fixed bed reactor and reacting same under preset conditions to form the acetoacetamide-N-sulfonic acid triethylamine salt. According to the method, a post-treatment process for the product is simplified, such that the final acesulfame potassium product has a better appearance; and the large-scale continuous production of an acetoacetamide-N-sulfonic acid triethylamine salt is achieved, the reaction time is shortened, the reaction yield is increased, and the production cost of acesulfame potassium is lowered.
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Inventors:
ZHOU RUI (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
DING ZHEN (CN)
CHEN YONGXU (CN)
YANG FENGBAO (CN)
LIU GANG (CN)
Application Number:
PCT/CN2021/097018
Publication Date:
December 01, 2022
Filing Date:
May 28, 2021
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07C303/34; C01B21/096; C07C209/68; C07C211/05; C07C307/02
Foreign References:
| CN111377834A | 2020-07-07 | |||
| CN103570592A | 2014-02-12 | |||
| CN108822004A | 2018-11-16 | |||
| CN105198778A | 2015-12-30 | |||
| CN108884064A | 2018-11-23 |
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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