Title:
METALLO-β-LACTAMASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/239872
Kind Code:
A1
Abstract:
The present invention provides: a compound represented by formula (I), formula (II), or formula (IV), or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition that is to be used for inhibiting metallo-β-lactamase and that contains said compound or a pharmaceutically acceptable salt thereof.
Inventors:
SAWA TOMOHIRO (JP)
YAMAGUTI YOSHIHIRO (JP)
ARAKAWA YOSHICHIKA (JP)
YAMAGUTI YOSHIHIRO (JP)
ARAKAWA YOSHICHIKA (JP)
Application Number:
PCT/JP2022/020285
Publication Date:
November 17, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
C07D499/68; A61K31/407; A61K31/43; A61K31/545; A61P31/04; C07D477/24; C07D501/28; C07D501/30
Domestic Patent References:
| WO2013109927A2 | 2013-07-25 |
Foreign References:
| JP2010119382A | 2010-06-03 | |||
| JP2011502103A | 2011-01-20 |
Other References:
MATSUSHITA HISASHI, SHIN MIZUKAMI, YUKI MORI, FUMINORI SUGIHARA, MASASHIRO SHIRAKAWA, YOSHICHIKA YOSHIOKA, KAZUYA KIKUCHI: "19F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface β-Lactamase Activity", CHEMBIOCHEM, vol. 13, no. 11, 6 July 2012 (2012-07-06), pages 1579 - 1583, XP093003490, DOI: 10.1002/cbic.201200331
MA, XIAO-YI; HAO, ZHI-FENG; LIU, WEN-FENG; YU, JIAN: "Synthesis of 6-Aminopenicilanic Acid Derivates with EDTA and DTPA", GUANGPU SHIYANSHI = CHINESE JOURNAL OF SPECTROSCOPY LABORATORY, ZHONGGUO KEXUEYUAN, HUAGONG YEJIN YANJIUSUO,, CN, vol. 28, no. 4, 1 July 2011 (2011-07-01), CN , pages 1612 - 1616, XP009541003, ISSN: 1004-8138
TAN, JIA-HAO; YANG, SHAO-BING; MA, XIAO-YI; HAO, ZHI-FENG: "Interaction of Ethylenediamine-N,N-Di(6-Aminopenicillanic Acid)-Diacetic Acid with Metal Ions", GUANGPU SHIYANSHI = CHINESE JOURNAL OF SPECTROSCOPY LABORATORY, ZHONGGUO KEXUEYUAN, HUAGONG YEJIN YANJIUSUO,, CN, vol. 30, no. 2, 1 January 2013 (2013-01-01), CN , pages 550 - 554, XP009541002, ISSN: 1004-8138
MA, XIAO-YI; HAO, ZHI-FENG; LIU, WEN-FENG; YU, JIAN: "Synthesis of 6-Aminopenicilanic Acid Derivates with EDTA and DTPA", GUANGPU SHIYANSHI = CHINESE JOURNAL OF SPECTROSCOPY LABORATORY, ZHONGGUO KEXUEYUAN, HUAGONG YEJIN YANJIUSUO,, CN, vol. 28, no. 4, 1 July 2011 (2011-07-01), CN , pages 1612 - 1616, XP009541003, ISSN: 1004-8138
TAN, JIA-HAO; YANG, SHAO-BING; MA, XIAO-YI; HAO, ZHI-FENG: "Interaction of Ethylenediamine-N,N-Di(6-Aminopenicillanic Acid)-Diacetic Acid with Metal Ions", GUANGPU SHIYANSHI = CHINESE JOURNAL OF SPECTROSCOPY LABORATORY, ZHONGGUO KEXUEYUAN, HUAGONG YEJIN YANJIUSUO,, CN, vol. 30, no. 2, 1 January 2013 (2013-01-01), CN , pages 550 - 554, XP009541002, ISSN: 1004-8138
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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