Title:
MEDICAL AGENT CONTAINING ACTIVE SULFUR COMPOUND AS MAIN INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/235494
Kind Code:
A1
Abstract:
Provided is a medical agent that exerts preventative and therapeutic effects against viral infections, by inhibiting proteases of viral origin on the basis of the effects of various physiological activities of an active sulfur compound present in vivo.
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Inventors:
AKAIKE TAKAAKI (JP)
TAKAGI SATOSHI (JP)
SUGIURA HISATOSHI (JP)
INABA KENJI (JP)
TAKAGI SATOSHI (JP)
SUGIURA HISATOSHI (JP)
INABA KENJI (JP)
Application Number:
PCT/JP2021/019023
Publication Date:
November 25, 2021
Filing Date:
May 19, 2021
Export Citation:
Assignee:
AKAIKE TAKAAKI (JP)
BIO XCELERATOR INC (JP)
BIO XCELERATOR INC (JP)
International Classes:
A61K45/00; A61K31/198; A61K38/06; A61K38/08; A61P11/00; A61P29/00; A61P31/12; A61P31/14; A61P37/02; C07K2/00; C07K5/037; C07K5/093; C12N9/99
Domestic Patent References:
| WO2019098877A1 | 2019-05-23 | |||
| WO2017057768A1 | 2017-04-06 | |||
| WO2017005768A1 | 2017-01-12 | |||
| WO2018117186A1 | 2018-06-28 |
Foreign References:
| JP2001511770A | 2001-08-14 | |||
| JP2001213774A | 2001-08-07 | |||
| JP2017543669A | 2016-09-30 |
Other References:
TADAHISA NUMAKURA, HISATOSHI SUGIURA, TAKAAKI AKAIKE, MASAKAZU ICHINOSE: "PP245: Study on the production of reactive sulfur species (reactive sulfur species: RSS) in patients with COPD", ANNALS OF THE JAPANESE RESPIRATORY SOCIETY, vol. 57, no. Spec. Iss., 2017, pages 191, XP009541467, ISSN: 2186-5876
ZHANG TIANLI, ONO KATSUHIKO, TSUTSUKI HIROYASU, IHARA HIDESHI, ISLAM WALIUL, AKAIKE TAKAAKI, SAWA TOMOHIRO: "Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock", CELL CHEMICAL BIOLOGY , ELSEVIER, AMSTERDAM, NL, vol. 26, no. 5, 1 May 2019 (2019-05-01), AMSTERDAM, NL , pages 686 - 698.e4, XP055875296, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.02.003
SAWA, TOMOHIRO: "Reactive sulfur derivatives strongly suppress the inflammatory responses", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 272, no. 11, 14 March 2020 (2020-03-14), JP , pages 1155 - 1157, XP009541529, ISSN: 0039-2359
SAWA TOMOHIRO : "Anti-inflammatory activity of reactive sulfur species: mechanisms and therapeutic potentials", NIPPON SAIKINGAKU ZASSHI, vol. 74, no. 1, 1 January 2019 (2019-01-01), pages 90 - 90, XP093010195, ISSN: 0021-4930, DOI: 10.3412/jsb.74.44
LINANI ABDERAHMANE, BENAROUS KHEDIDJA, YOUSFI MOHAMED: "Novel Structural Mechanism of Glutathione as a potential peptide inhibitor to the main protease (M pro ): CoviD-19 treatment, Molecular docking and SAR study", CHEMRXIV, 21 April 2020 (2020-04-21), XP055875314, Retrieved from the Internet [retrieved on 20211221]
JIN ZHENMING; DU XIAOYU; XU YECHUN; DENG YONGQIANG; LIU MEIQIN; ZHAO YAO; ZHANG BING; LI XIAOFENG; ZHANG LEIKE; PENG CHAO; DUAN YI: "Structure of Mfrom SARS-CoV-2 and discovery of its inhibitors", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 582, no. 7811, 9 April 2020 (2020-04-09), London, pages 289 - 293, XP037163556, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2223-y
MATSUNAGA, TETSURO ET AL.: "Development of prevention and therapeutics for novel coronavirus infections by reactive sulfur species", LECTURE ABSTRACTS OF THE 31ST ANNUAL MEETING OF THE JAPANESE SOCIETY FOR HOST DEFENSE RESEARCH, 1 October 2020 (2020-10-01), pages 40
DAVIS DAVID A., BULUT HAYDAR, SHRESTHA PRABHA, YAPARLA AMULYA, JAEGER HANNAH K., HATTORI SHIN-ICHIRO, WINGFIELD PAUL T., MITSUYA H: "Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300", BIORXIV, 12 April 2021 (2021-04-12), XP055875321, Retrieved from the Internet [retrieved on 20211221], DOI: 10.1101/2021.04.09.439169
"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics", NATURE COMMUNICATIONS, vol. 18, 27 October 2017 (2017-10-27), pages 1177
ZHANG L ET AL.: "Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a ketoamide inhibitors", SCIENCE, vol. 368, 2020, pages 409 - 412, XP055814007, DOI: 10.1126/science.abb3405
JIN Z ET AL.: "Structure of Mpro from COVID-19 virus and discovery of its inhibitors", NATURE, vol. 582, 2020, pages 289 - 293
AKAIKE T. ET AL., JOURNAL OF INFECTIOUS DISEASES, vol. 170, 1994, pages 1023 - 1026
PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), Retrieved from the Internet
ZHANG TIANLI, ONO KATSUHIKO, TSUTSUKI HIROYASU, IHARA HIDESHI, ISLAM WALIUL, AKAIKE TAKAAKI, SAWA TOMOHIRO: "Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock", CELL CHEMICAL BIOLOGY , ELSEVIER, AMSTERDAM, NL, vol. 26, no. 5, 1 May 2019 (2019-05-01), AMSTERDAM, NL , pages 686 - 698.e4, XP055875296, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.02.003
SAWA, TOMOHIRO: "Reactive sulfur derivatives strongly suppress the inflammatory responses", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 272, no. 11, 14 March 2020 (2020-03-14), JP , pages 1155 - 1157, XP009541529, ISSN: 0039-2359
SAWA TOMOHIRO : "Anti-inflammatory activity of reactive sulfur species: mechanisms and therapeutic potentials", NIPPON SAIKINGAKU ZASSHI, vol. 74, no. 1, 1 January 2019 (2019-01-01), pages 90 - 90, XP093010195, ISSN: 0021-4930, DOI: 10.3412/jsb.74.44
LINANI ABDERAHMANE, BENAROUS KHEDIDJA, YOUSFI MOHAMED: "Novel Structural Mechanism of Glutathione as a potential peptide inhibitor to the main protease (M pro ): CoviD-19 treatment, Molecular docking and SAR study", CHEMRXIV, 21 April 2020 (2020-04-21), XP055875314, Retrieved from the Internet
JIN ZHENMING; DU XIAOYU; XU YECHUN; DENG YONGQIANG; LIU MEIQIN; ZHAO YAO; ZHANG BING; LI XIAOFENG; ZHANG LEIKE; PENG CHAO; DUAN YI: "Structure of Mfrom SARS-CoV-2 and discovery of its inhibitors", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 582, no. 7811, 9 April 2020 (2020-04-09), London, pages 289 - 293, XP037163556, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2223-y
MATSUNAGA, TETSURO ET AL.: "Development of prevention and therapeutics for novel coronavirus infections by reactive sulfur species", LECTURE ABSTRACTS OF THE 31ST ANNUAL MEETING OF THE JAPANESE SOCIETY FOR HOST DEFENSE RESEARCH, 1 October 2020 (2020-10-01), pages 40
DAVIS DAVID A., BULUT HAYDAR, SHRESTHA PRABHA, YAPARLA AMULYA, JAEGER HANNAH K., HATTORI SHIN-ICHIRO, WINGFIELD PAUL T., MITSUYA H: "Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300", BIORXIV, 12 April 2021 (2021-04-12), XP055875321, Retrieved from the Internet
"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics", NATURE COMMUNICATIONS, vol. 18, 27 October 2017 (2017-10-27), pages 1177
ZHANG L ET AL.: "Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a ketoamide inhibitors", SCIENCE, vol. 368, 2020, pages 409 - 412, XP055814007, DOI: 10.1126/science.abb3405
JIN Z ET AL.: "Structure of Mpro from COVID-19 virus and discovery of its inhibitors", NATURE, vol. 582, 2020, pages 289 - 293
AKAIKE T. ET AL., JOURNAL OF INFECTIOUS DISEASES, vol. 170, 1994, pages 1023 - 1026
PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), Retrieved from the Internet
Attorney, Agent or Firm:
OHGA, Shinji et al. (JP)
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