MACROCYCLIC INDOLES AS MCL-1 INHIBITORS - ASCENTAGE PHARMA SUZHOU CO LTD

Title:

MACROCYCLIC INDOLES AS MCL-1 INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2020/103864

Kind Code:

A1

Abstract:

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L1, L2, L3, Ⓐ, Ⓑ, Ⓒ are as defined as set forth in the specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

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Inventors:

CHEN HAO (CN)
CHEN WENMING (CN)
LI CHAO (CN)
LI DONGBO (CN)
JING YU (CN)
TANG GUOZHI (CN)
ZHOU YUNLONG (CN)
WANG SHAOMENG (US)
YANG CHAO-YIE (US)

Application Number:

PCT/CN2019/119698

Publication Date:

May 28, 2020

Filing Date:

November 20, 2019

Export Citation:

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Assignee:

ASCENTAGE PHARMA SUZHOU CO LTD (CN)
UNIV MICHIGAN REGENTS (US)
ASCENTAGE PHARMA GROUP CORP LTD (CN)

International Classes:

C07D497/22; A61K31/395; A61P35/00; C07D231/12; C07D515/22

Domestic Patent References:

WO2018178226A1	2018-10-04
WO2018178226A1	2018-10-04
WO2018178227A1	2018-10-04
WO2018178227A1	2018-10-04

Foreign References:

US20170305926A1	2017-10-26
US20170305926A1	2017-10-26
CN106456602A	2017-02-22
CN106456602A	2017-02-22

Other References: