Title:
LURBINECTEDIN CRYSTAL FORM AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/193440
Kind Code:
A1
Abstract:
Provided is a lurbinectedin crystal form having characteristic absorption peaks at diffraction angles 2θ of 4.55 ± 0.2°, 6.16 ± 0.2°, 7.61 ± 0.2°, 9.17 ± 0.2°, 9.54 ± 0.2°, and 9.89 ± 0.2° in an X-ray powder diffraction pattern using a Cu-Kα radiation source. Also provided are novel lurbinectedin crystal forms II, III, IV, and V. The crystal forms I-V features high purity, good stability, good solubility and the like, the absence of the problems of difficulties in filtration and static electricity in the prior art, a simple preparation method, available and cost-efficient solvents, mild crystallization conditions, and suitability for industrial mass production.
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Inventors:
ZHOU HOUJIA (CN)
CHEN YUFENG (CN)
QIAN KAIMIN (CN)
CHEN JIAN (CN)
CAI LINGLI (CN)
GAO QIANG (CN)
ZHENG BAOFU (CN)
CHEN YUFENG (CN)
QIAN KAIMIN (CN)
CHEN JIAN (CN)
CAI LINGLI (CN)
GAO QIANG (CN)
ZHENG BAOFU (CN)
Application Number:
PCT/CN2022/131995
Publication Date:
October 12, 2023
Filing Date:
November 15, 2022
Export Citation:
Assignee:
SHANGHAI HAOYUAN CHEMEXPRESS CO LTD (CN)
International Classes:
C07D515/22; A61K31/4995; A61P35/00
Domestic Patent References:
| WO2021098992A1 | 2021-05-27 | |||
| WO2021099635A1 | 2021-05-27 |
Foreign References:
| CN115304619A | 2022-11-08 | |||
| CN114940682A | 2022-08-26 | |||
| CN115246846A | 2022-10-28 | |||
| CN1564822A | 2005-01-12 | |||
| CN103038240A | 2013-04-10 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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