Title:
LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067811
Kind Code:
A1
Abstract:
Provided herein are compounds having formulas (I) or (VII) or pharmaceutically acceptable salts, tautomers, isotopologues, stereoisomers, or prodrugs thereof; ligand-drug conjugates and pharmaceutically acceptable salts or solvates thereof, wherein the ligand-drug conjugate comprises a residue of the compound provided here; and methods of treating cancer thereof.
Inventors:
TSAI CHARNG-SHENG (CN)
TSAI MEI-HSUAN (CN)
LI BING (CN)
XUE LIU (CN)
HE MAOMAO (CN)
WANG ZEWEI (CN)
LUO WEI (CN)
QU YI (CN)
YANG XIAOKUN (CN)
WANG CE (CN)
TSAI MEI-HSUAN (CN)
LI BING (CN)
XUE LIU (CN)
HE MAOMAO (CN)
WANG ZEWEI (CN)
LUO WEI (CN)
QU YI (CN)
YANG XIAOKUN (CN)
WANG CE (CN)
Application Number:
PCT/CN2023/122616
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
BEIGENE LTD (GB)
TSAI CHARNG SHENG (CN)
TSAI CHARNG SHENG (CN)
International Classes:
C07D491/22; A61K31/4745; A61K39/395; A61P35/00; C07K16/28
Domestic Patent References:
| WO2023217064A1 | 2023-11-16 | |||
| WO2023004266A1 | 2023-01-26 | |||
| WO2022236136A1 | 2022-11-10 | |||
| WO2022068878A1 | 2022-04-07 | |||
| WO2022166762A1 | 2022-08-11 | |||
| WO2015155998A1 | 2015-10-15 | |||
| WO2022078260A1 | 2022-04-21 | |||
| WO2022056696A1 | 2022-03-24 | |||
| WO2020063676A1 | 2020-04-02 | |||
| WO2021052402A1 | 2021-03-25 | |||
| WO2021249228A1 | 2021-12-16 | |||
| WO2022015656A1 | 2022-01-20 |
Foreign References:
| CN115850291A | 2023-03-28 | |||
| JPH0687746A | 1994-03-29 | |||
| CN104755494A | 2015-07-01 | |||
| CN111689980A | 2020-09-22 |
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF:
Previous Patent: ANTI-GPR183 ANTIBODIES AND USES THEREOF
Next Patent: AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Next Patent: AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF