Title:
LEUKOCYTE-DERIVED IMMUNOMAGNETIC PARTICLE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/043256
Kind Code:
A1
Abstract:
The present invention relates to a leukocyte-derived immunomagnetic particle and use thereof. More particularly, the present invention relates to an immunomagnetic particle, a method for detecting a pathogenic substance by using the immunomagnetic particle, and a method for diagnosing and treating an infectious disease, wherein the immunomagnetic particle comprises: a cell membrane derived from leukocytes capable of capturing pathogenic substances; and magnetic particles attached to the cell membrane. The leukocyte-derived immunomagnetic particle according to an aspect includes a cell membrane derived from leukocytes capable of capturing pathogenic substances so that side effects in a living body can be minimized, and due to the characteristics of the leukocytes from which the cell membrane is derived, various types of pathogenic substances can be detected. In addition, by including magnetic particles, the immunomagnetic particle can be simply separated by applying a magnetic field thereto, and thus pathogenic substances can be more effectively detected and removed.
Inventors:
KANG JOO HUN (KR)
KWON SEYONG (KR)
PARK SUNG JIN (KR)
KWON SEYONG (KR)
PARK SUNG JIN (KR)
Application Number:
PCT/KR2022/013867
Publication Date:
March 23, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
International Classes:
C12N5/0786; A61K35/15; B03C1/02
Foreign References:
| KR20190103819A | 2019-09-05 | |||
| CN109507418A | 2019-03-22 |
Other References:
RAVENHILL BENJAMIN J., SODAY LIOR, HOUGHTON JACK, ANTROBUS ROBIN, WEEKES MICHAEL P.: "Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 January 2020 (2020-01-01), pages 4560, XP093047862, DOI: 10.1038/s41598-020-61356-w
KE XIONG, WEI WEI, YONGJIE JIN, SHUMIN WANG, DONGXU ZHAO, SHUANG WANG, XIAOYONG GAO, CHENMENG QIAO, HUA YUE, GUANGHUI MA, HAI-YAN : "Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 28, no. 36, 1 September 2016 (2016-09-01), DE , pages 7929 - 7935, XP055534821, ISSN: 0935-9648, DOI: 10.1002/adma.201601643
WANG ZIXIANG, CHENG LIN, SUN YUE, WEI XIAOYUN, CAI BO, LIAO LEI, ZHANG YUANZHEN, ZHAO XING-ZHONG: "Enhanced Isolation of Fetal Nucleated Red Blood Cells by Enythrocyte-Leukocyte Hybrid Membrane-Coated Magnetic Nanoparticles for Noninvasive Pregnant Diagnostics", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 93, no. 2, 19 January 2021 (2021-01-19), US , pages 1033 - 1042, XP093047863, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.0c03933
KE XIONG, WEI WEI, YONGJIE JIN, SHUMIN WANG, DONGXU ZHAO, SHUANG WANG, XIAOYONG GAO, CHENMENG QIAO, HUA YUE, GUANGHUI MA, HAI-YAN : "Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 28, no. 36, 1 September 2016 (2016-09-01), DE , pages 7929 - 7935, XP055534821, ISSN: 0935-9648, DOI: 10.1002/adma.201601643
WANG ZIXIANG, CHENG LIN, SUN YUE, WEI XIAOYUN, CAI BO, LIAO LEI, ZHANG YUANZHEN, ZHAO XING-ZHONG: "Enhanced Isolation of Fetal Nucleated Red Blood Cells by Enythrocyte-Leukocyte Hybrid Membrane-Coated Magnetic Nanoparticles for Noninvasive Pregnant Diagnostics", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 93, no. 2, 19 January 2021 (2021-01-19), US , pages 1033 - 1042, XP093047863, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.0c03933
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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