Title:
KIF18A PROTEIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/083208
Kind Code:
A1
Abstract:
Provided in the present invention are a compound having a structure as represented by general formula (I); a deuterated substance, a stereoisomer or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing same; and the use thereof. The compound provided in the present invention has a good KIF18A protein inhibition effect, and can be used for treating and/or preventing advanced or metastatic colon cancer, breast cancer, lung cancer, pancreatic cancer, prostate cancer, bladder cancer, head cancer, neck cancer, cervical cancer, peritoneal cancer, fallopian tube cancer, ovarian cancer or endometrial cancer.
Inventors:
WEN QIAODONG (CN)
YANG XIN (CN)
JIANG SHANLING (CN)
ZHUGE DINGJUAN (CN)
ZHENG MEI (CN)
YIN JIANMING (CN)
LV YUBIN (CN)
YANG XIN (CN)
JIANG SHANLING (CN)
ZHUGE DINGJUAN (CN)
ZHENG MEI (CN)
YIN JIANMING (CN)
LV YUBIN (CN)
Application Number:
PCT/CN2023/125527
Publication Date:
April 25, 2024
Filing Date:
October 20, 2023
Export Citation:
Assignee:
HANGZHOU BANGSHUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D413/14; A61K31/497; A61P35/00
Domestic Patent References:
| WO2021211549A1 | 2021-10-21 | |||
| WO2020132651A1 | 2020-06-25 | |||
| WO2020132653A1 | 2020-06-25 | |||
| WO2020132648A1 | 2020-06-25 | |||
| WO2021026098A1 | 2021-02-11 | |||
| WO2021026099A1 | 2021-02-11 | |||
| WO2021026100A1 | 2021-02-11 | |||
| WO2022268230A1 | 2022-12-29 | |||
| WO2023041055A1 | 2023-03-23 | |||
| WO2023088441A1 | 2023-05-25 | |||
| WO2023174175A1 | 2023-09-21 |
Foreign References:
| CN115785068A | 2023-03-14 |
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