Title:
KERATIN YK93-9, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/074111
Kind Code:
A1
Abstract:
The present invention pertains to the field of biopharmaceuticals and provides a keratin YK93-9, a nucleic acid molecule encoding same, an expression vector comprising the nucleic acid molecule, a host cell that contains the expression vector or whose genome is integrated with the nucleic acid molecule, a preparation method therefor, and a pharmaceutical composition thereof. The present invention also provides use of the described keratin YK93-9 among other substances in the preparation of medicaments for treating lung cancer, lymphoma, breast cancer, melanoma, uterine myoma, prostate hyperplasia, and the like.
Inventors:
YU SHISHAN (CN)
CHEN XIAOGUANG (CN)
LIU YUNBAO (CN)
JIN JING (CN)
QU JING (CN)
LI MI (CN)
JIANG HUIMIN (CN)
WANG XIAOJING (CN)
SHI GUORU (CN)
HAO MENGYAO (CN)
LI YONG (CN)
MA SHUANGGANG (CN)
WANG MINGJIN (CN)
FU JIANG (CN)
LI SHUYING (CN)
SU GUOZHU (CN)
CHEN XIAOGUANG (CN)
LIU YUNBAO (CN)
JIN JING (CN)
QU JING (CN)
LI MI (CN)
JIANG HUIMIN (CN)
WANG XIAOJING (CN)
SHI GUORU (CN)
HAO MENGYAO (CN)
LI YONG (CN)
MA SHUANGGANG (CN)
WANG MINGJIN (CN)
FU JIANG (CN)
LI SHUYING (CN)
SU GUOZHU (CN)
Application Number:
PCT/CN2023/121681
Publication Date:
April 11, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07K14/47; A61K38/17; A61P13/08; A61P29/00; A61P35/00; C12N1/21; C12N15/12; C12N15/70; C12P21/02
Foreign References:
| CN112794894A | 2021-05-14 | |||
| CN116535486A | 2023-08-04 |
Other References:
DATABASE Protein 28 October 2020 (2020-10-28), ANONYMOUS: "keratin, type II cytoskeletal 5 [Manis pentadactyla] ", XP093155715, retrieved from NCBI Database accession no. XP_036771062.1
ZHENG WEN: "Construction of keratin 5-IRES-eGFP knockin hESCs cell line", JOURNAL OF DIAGNOSIS AND THERAPY ON DERMATO-VENEREOLOGY, vol. 29, no. 4, 15 August 2022 (2022-08-15), pages 299 - 304, XP093155724
LI JUNXIA: " The Expression Changes And Significance of EGFR And Cytokeratin 5 in Triple Negative Breast Cancer Tissues", SHANDONG MEDICAL JOURNAL, vol. 55, no. 43, 20 November 2015 (2015-11-20), pages 74 - 75, XP093155725
ZHENG WEN: "Construction of keratin 5-IRES-eGFP knockin hESCs cell line", JOURNAL OF DIAGNOSIS AND THERAPY ON DERMATO-VENEREOLOGY, vol. 29, no. 4, 15 August 2022 (2022-08-15), pages 299 - 304, XP093155724
LI JUNXIA: " The Expression Changes And Significance of EGFR And Cytokeratin 5 in Triple Negative Breast Cancer Tissues", SHANDONG MEDICAL JOURNAL, vol. 55, no. 43, 20 November 2015 (2015-11-20), pages 74 - 75, XP093155725
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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