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Title:
IONIZABLE LIPID COMPOUND HAVING HIGH TRANSFECTION EFFICIENCY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067639
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine. Disclosed are an ionizable lipid compound having high transfection efficiency and a use thereof. The ionizable lipid compound is a compound having the following structure: formula (I), wherein n=0-10; G1 and G2 are each independently an alkylene group; R1, R2, R3, and R4 are each independently an alkane group, an olefin group, or H; G3 is an alkylene group or formula (II). A lipid nanoparticle carrier prepared from the compound of the present invention has good cytocompatibility in a physiological environment, can promote endosomal escape in an intracellular endosome acidic environment, has unexpected progress in improving the transfection effect and has high safety, and is suitable for biomedical industrialization.

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Inventors:
ZHANG XUEQING (CN)
TENG YILONG (CN)
CHEN QIJING (CN)
Application Number:
PCT/CN2023/121746
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
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Assignee:
RONGCAN SHANGHAI BIOTECH CO LTD (CN)
International Classes:
C07C229/12; A61K9/51; A61K31/7088; A61K31/7105; A61K47/18; A61P35/00; A61P43/00
Domestic Patent References:
WO2022140239A12022-06-30
WO2023107669A12023-06-15
Foreign References:
CN114728886A2022-07-08
CN113402405A2021-09-17
CN114728887A2022-07-08
CN115784920A2023-03-14
CN115232128A2022-10-25
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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