INFLAMMATION-SUPPRESSING MICROORGANISM AND PRODUCTION METHOD FOR SAME

WIPO Patent Application WO/2024/096121

A1

The present disclosure provides a bacterial preparation that can be used to treat inflammatory bowel disease. More specifically, the present disclosure relates to a microorganism in which a gene from at least one of a fimbria operon gene group, a pilus-associated gene group, and a two-component regulatory system gene group has been modified. The modification suppresses inflammation in a host compared to microorganisms in which the gene is unmodified.

KIRA SHINTARO (JP)
TAMIYA TAIGA (JP)
OKUMURA RYO (JP)

PCT/JP2023/039715

May 10, 2024

November 02, 2023

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BIO PALETTE CO LTD (JP)

C12N1/21; A61K35/66; A61K35/74; A61K48/00; A61P29/00; A61P43/00; C07K14/245; C12N1/20; C12N15/09; C12N15/31; C12Q1/02

US20190201457A1	2019-07-04
CN111690585A	2020-09-22

HYUNGJUN YANG: "Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts", GUT MICROBES, LANDES BIOSCIENCE, UNITED STATES, vol. 12, no. 1, 9 November 2020 (2020-11-09), United States , pages 1847976, XP093166545, ISSN: 1949-0976, DOI: 10.1080/19490976.2020.1847976
RUBÍ VEGA-HERNÁNDEZ: "Flagella, Type I Fimbriae and Curli of Uropathogenic Escherichia coli Promote the Release of Proinflammatory Cytokines in a Coculture System", MICROORGANISMS, MDPI AG, vol. 9, no. 11, 27 October 2021 (2021-10-27), pages 2233, XP093166547, ISSN: 2076-2607, DOI: 10.3390/microorganisms9112233

KAMADA, Mitsunori et al. (JP)

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