Title:
INDUCED REGULATORY T CELLS CONTAINING CHIMERIC ANTIGEN RECEPTOR (CAR)
Document Type and Number:
WIPO Patent Application WO/2024/071039
Kind Code:
A1
Abstract:
The present disclosure provides a pharmaceutical composition for treating or preventing T cell-related disorders, the pharmaceutical composition containing induced regulatory T cells having high functionality and a stable immunosuppression action. Also provided are induced regulatory T cells containing a chimeric antigen receptor (CAR). The present disclosure provides the pharmaceutical composition for treating or preventing T cell-related disorders, the composition containing, as an active ingredient, induced regulatory T cells having at least one characteristic selected from the group consisting of CTLA4 positivity, NT5E positivity, ITGAE (CD103) positivity, and AREG positivity. The present disclosure provides induced regulatory T cells containing a chimeric antigen receptor (CAR).
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Inventors:
MIKAMI NORIHISA (JP)
SAKAGUCHI SHIMON (JP)
NARUMIYA SHUH (JP)
SAKAGUCHI SHIMON (JP)
NARUMIYA SHUH (JP)
Application Number:
PCT/JP2023/034731
Publication Date:
April 04, 2024
Filing Date:
September 25, 2023
Export Citation:
Assignee:
REGCELL CO LTD (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12N5/10; A61K35/17; A61P1/04; A61P3/00; A61P3/10; A61P5/14; A61P7/06; A61P9/04; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P21/02; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; C07K14/495; C07K14/55; C07K16/28; C07K19/00; C12N5/0783; C12N15/09; C12P21/08
Domestic Patent References:
| WO2007037544A1 | 2007-04-05 |
Foreign References:
| US20220184121A1 | 2022-06-16 | |||
| JP2013501057A | 2013-01-10 | |||
| JP2021534783A | 2021-12-16 |
Other References:
HYE-JI WON: "Construction of CAR-iTreg (Chimeric antigen receptor-inducible Treg) for inducing tolerance in transplantation", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 202, no. 1_Supplement, 1 May 2019 (2019-05-01), US , pages 57.22, XP093156148, ISSN: 0022-1767, DOI: 10.4049/jimmunol.202.Supp.57.22
NA TANG, CHEN CHENG, XINGYING ZHANG, MIAOMIAO QIAO, NA LI, WEI MU, XIAO-FEI WEI, WEIDONG HAN, HAOYI WANG: "TGF-&B inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors", JCI INSIGHT, vol. 5, no. 4, 27 February 2020 (2020-02-27), XP055706424, DOI: 10.1172/jci.insight.133977
ESMAEILZADEH ABDOLREZA; TAHMASEBI SAFA; ATHARI SEYYED SHAMSADIN: "Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 123, 17 December 2019 (2019-12-17), FR , XP086010681, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.109685
VARUN SASIDHARAN NAIR, SONG MI HYE, OH KWON IK: "Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 196, no. 5, 1 March 2016 (2016-03-01), US , pages 2119 - 2131, XP055687324, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1502352
XIAOJING YUE: "Control of Foxp3 stability through modulation of TET activity", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 213, no. 3, 7 March 2016 (2016-03-07), US , pages 377 - 397, XP093156154, ISSN: 0022-1007, DOI: 10.1084/jem.20151438
NA TANG, CHEN CHENG, XINGYING ZHANG, MIAOMIAO QIAO, NA LI, WEI MU, XIAO-FEI WEI, WEIDONG HAN, HAOYI WANG: "TGF-&B inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors", JCI INSIGHT, vol. 5, no. 4, 27 February 2020 (2020-02-27), XP055706424, DOI: 10.1172/jci.insight.133977
ESMAEILZADEH ABDOLREZA; TAHMASEBI SAFA; ATHARI SEYYED SHAMSADIN: "Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 123, 17 December 2019 (2019-12-17), FR , XP086010681, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.109685
VARUN SASIDHARAN NAIR, SONG MI HYE, OH KWON IK: "Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 196, no. 5, 1 March 2016 (2016-03-01), US , pages 2119 - 2131, XP055687324, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1502352
XIAOJING YUE: "Control of Foxp3 stability through modulation of TET activity", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 213, no. 3, 7 March 2016 (2016-03-07), US , pages 377 - 397, XP093156154, ISSN: 0022-1007, DOI: 10.1084/jem.20151438
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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