Title:
INDOLINE COMPOUND AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/031753
Kind Code:
A1
Abstract:
The present invention provides a preparation method for an indoline compound. The indoline compound is prepared by conducting a cyclization rearrangement reaction of N-arylsulfonyl-2-β,γ-unsaturated olefin-substituted aniline by means of a visible light and metal complex catalysis method. The indoline compound prepared by the present invention has a specific structure, and an environmentally friendly catalytic method that involves no use of such additives as transition metals and oxidants is used in the preparation method. The reaction conditions are mild, and the method is simple and efficient; meanwhile, the substrate is widely applicable. The present invention further provides an indoline compound and use thereof.
Inventors:
LIU FENG (CN)
TANG WAN (CN)
AO GUIZHEN (CN)
TANG WAN (CN)
AO GUIZHEN (CN)
Application Number:
PCT/CN2022/115450
Publication Date:
February 15, 2024
Filing Date:
August 29, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07D513/04; C07D513/10
Domestic Patent References:
| WO2011009059A2 | 2011-01-20 |
Foreign References:
| JP2018127411A | 2018-08-16 | |||
| CN102869662A | 2013-01-09 | |||
| CN111138338A | 2020-05-12 | |||
| CN111362973A | 2020-07-03 | |||
| CN115073495A | 2022-09-20 |
Other References:
SHERMAN ERIC S., SHERRY R. CHEMLER, TAI BOON TAN, OKSANA GERLITS: "Copper(II) Acetate Promoted Oxidative Cyclization of Arylsulfonyl-o-allylanilines", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 10, 7 April 2004 (2004-04-07), US , pages 1573 - 1575, XP093139964, ISSN: 1523-7060
LIU XIAO-YU, QIN YONG: "Indole Alkaloid Synthesis Facilitated by Photoredox Catalytic Radical Cascade Reactions", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 52, no. 7, 16 July 2019 (2019-07-16), US , pages 1877 - 1891, XP093139966, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.9b00246
TANG WAN, YAN DUAN-YANG, LIANG KAI-CHENG, SU MA, LIU FENG: "Radical-mediated alkene carboamination/dearomatization of arylsulfonyl- o -allylanilines via photoredox catalysis", ORGANIC CHEMISTRY FRONTIERS, vol. 9, no. 23, 22 November 2022 (2022-11-22), pages 6535 - 6539, XP093139968, ISSN: 2052-4129, DOI: 10.1039/D2QO01221A
LIU XIAO-YU, QIN YONG: "Indole Alkaloid Synthesis Facilitated by Photoredox Catalytic Radical Cascade Reactions", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 52, no. 7, 16 July 2019 (2019-07-16), US , pages 1877 - 1891, XP093139966, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.9b00246
TANG WAN, YAN DUAN-YANG, LIANG KAI-CHENG, SU MA, LIU FENG: "Radical-mediated alkene carboamination/dearomatization of arylsulfonyl- o -allylanilines via photoredox catalysis", ORGANIC CHEMISTRY FRONTIERS, vol. 9, no. 23, 22 November 2022 (2022-11-22), pages 6535 - 6539, XP093139968, ISSN: 2052-4129, DOI: 10.1039/D2QO01221A
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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