Title:
IMIDAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2024/080361
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. The compound of the invention has excellent α1A adrenergic receptor agonist activity and is useful as a prophylactic drug or therapeutic drug for orthostatic hypotension, essential hypotension, acute hypotension associated with various diseases or conditions, and urinary incontinence. [In the formula: R1 represents a hydrogen atom or a C1-C3 alkyl group; and Z is selected from the group consisting of a substituted phenylamino group, a substituted phenyloxy group, a substituted phenylthio group, a substituted thienylamino group, etc.]
Inventors:
SAKAI KEITA (JP)
KAWAKAMI YURIKO (JP)
TAKASU NORIAKI (JP)
MAEDA HIROYUKI (JP)
TANAKA GAKU (JP)
NAGANO HIROKI (JP)
HASHIMOTO SHINJI (JP)
TORII MASAFUMI (JP)
MORIMOTO NOBUTAKA (JP)
MIYAZATO KENJI (JP)
KAWAKAMI YURIKO (JP)
TAKASU NORIAKI (JP)
MAEDA HIROYUKI (JP)
TANAKA GAKU (JP)
NAGANO HIROKI (JP)
HASHIMOTO SHINJI (JP)
TORII MASAFUMI (JP)
MORIMOTO NOBUTAKA (JP)
MIYAZATO KENJI (JP)
Application Number:
PCT/JP2023/037190
Publication Date:
April 18, 2024
Filing Date:
October 13, 2023
Export Citation:
Assignee:
SANWA KAGAKU KENKYUSHO CO (JP)
International Classes:
C07D409/14; A61K31/4178; A61K31/427; A61K31/4436; A61K31/4439; A61K31/497; A61K31/506; A61P9/02; C07D401/12; C07D407/12; C07D409/12; C07D417/12; C07D417/14
Foreign References:
| JP2002543187A | 2002-12-17 | |||
| JP2006525970A | 2006-11-16 |
Other References:
BISHOP M J, ET AL.: "ALPHA1-ADRENOCEPTER AGONISTS: THE IDENTIFICATION OF NOVEL ALPHA1A SUBTYPE SELECTIVE 2'-HETEROARYL-2-(PHENOXYMETHYL)IMIDAZOLINES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 12, no. 3, 11 February 2002 (2002-02-11), Amsterdam NL , pages 471 - 475, XP001095562, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)00764-8
FRANK NAVAS: "2-(Anilinomethyl)imidazolines as 1A Adrenergic Receptor Agonists: 2 0 -Heteroaryl and 2 0 -Oxime Ether Series", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 1 January 2002 (2002-01-01), pages 575 - 579, XP093157867
SPEAKE J D,ET AL: "2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 13, no. 6, 24 March 2003 (2003-03-24), Amsterdam NL , pages 1183 - 1186, XP002270331, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(03)00050-7
HODSON S. J. , ET AL: "Alpha1-Adrenoceptor Activation: A Comparison of 4-(Anilinomethyl)imidazoles and 4-(Phenoxymethyl)imidazoles to Related 2-Imidazolines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 12, 1 January 2002 (2002-01-01), Amsterdam NL , pages 3449 - 3452, XP002307084, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00753-9
YOSHIYA AMEMIYA, SEOUNG S. HONG, BURRAH V. VENKATARAMAN, POPAT N. PATIL, GAMAL SHAMS, KARL ROMSTEDT: "Synthesis and .alpha.-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 4, 1 January 1992 (1992-01-01), US , pages 750 - 755, XP002472949, ISSN: 0022-2623, DOI: 10.1021/jm00082a017
FRANK NAVAS: "2-(Anilinomethyl)imidazolines as 1A Adrenergic Receptor Agonists: 2 0 -Heteroaryl and 2 0 -Oxime Ether Series", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 1 January 2002 (2002-01-01), pages 575 - 579, XP093157867
SPEAKE J D,ET AL: "2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 13, no. 6, 24 March 2003 (2003-03-24), Amsterdam NL , pages 1183 - 1186, XP002270331, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(03)00050-7
HODSON S. J. , ET AL: "Alpha1-Adrenoceptor Activation: A Comparison of 4-(Anilinomethyl)imidazoles and 4-(Phenoxymethyl)imidazoles to Related 2-Imidazolines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 12, 1 January 2002 (2002-01-01), Amsterdam NL , pages 3449 - 3452, XP002307084, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00753-9
YOSHIYA AMEMIYA, SEOUNG S. HONG, BURRAH V. VENKATARAMAN, POPAT N. PATIL, GAMAL SHAMS, KARL ROMSTEDT: "Synthesis and .alpha.-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 4, 1 January 1992 (1992-01-01), US , pages 750 - 755, XP002472949, ISSN: 0022-2623, DOI: 10.1021/jm00082a017
Attorney, Agent or Firm:
SAKAMOTO & PARTNERS (JP)
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