Title:
HYPERBRANCHED POLYLYSINE-CONTAINING POLYURETHANE HEART PATCH AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/231045
Kind Code:
A1
Abstract:
Disclosed are a hyperbranched polylysine-containing polyurethane heart patch and a preparation method therefor. The heart patch comprises a polyurethane formed by polymerizing an unsaturated polyester diol and comprises hyperbranched polylysines containing amino groups at the ends. The hyperbranched polylysines are grafted onto the surface of the polyurethane with a grafting degree of 40-60%. The preparation method comprises: preparing a polyurethane material and processing the material into a patch, and grafting hyperbranched polylysines to the surface of the polyurethane patch by means of Michael addition reactions of double bonds and amino groups, so as to prepare the hyperbranched polylysine-containing polyurethane heart patch. The processability of the polyurethane endows the heart patch with various possible structures, and meanwhile, the grafting of the hyperbranched polylysines further improves the hydrophilicity and cell compatibility of the heart patch, favoring the application of the patch to the treatment of myocardial infarction in the body.
Inventors:
GAO CHANGYOU (CN)
XIE JIEQI (CN)
XIE JIEQI (CN)
Application Number:
PCT/CN2022/097156
Publication Date:
December 07, 2023
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61L27/18; A61L27/50; A61L27/54; C08G81/00
Foreign References:
| CN111035803A | 2020-04-21 | |||
| CN104387553A | 2015-03-04 | |||
| CN113425897A | 2021-09-24 |
Other References:
DUAN, YIYUAN ET AL.: "Unsaturated Polyurethane Films Grafted with Enantiomeric Polylysine Promotes Macrophage Polarization to a M2 Phenotype through PI3/KAkt1/mTOR Axis.", BIOMATERIALS, vol. 246, 31 March 2020 (2020-03-31), XP086130309, DOI: 10.1016/j.biomaterials.2020.120012
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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