HYDRONAPHTHOQUINOLINE DERIVATIVE

WIPO Patent Application WO/2016/084790

A1

The present invention provides a compound represented by general formula (I) which has excellent retinoic acid receptor-related orphan receptor γt inhibitory activity and IL-17 production inhibitory activity, or a pharmaceutically acceptable salt thereof. (In the formula, U represents a phenyl group, pyridyl group, tetrahydrofuryl group, tetrahydropyranyl group or benzyl group which may be independently mono- to tetra-substituted by groups selected from among halogen atoms, C1-C6 alkyl groups and C1-C6 alkoxy groups, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group or the like; R1 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R2 represents a hydrogen atom or a C1-C6 alkyl group; R3 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R4 represents a hydrogen atom or the like; R5 represents a C1-C6 alkyl group which may be independently mono- to tetra-substituted by groups selected from among a hydroxyl group and C1-C6 alkoxy groups, a hydrogen atom or the like; R6 represents a C1-C6 alkyl group which may be independently mono- or di-substituted by groups selected from among C1-C6 alkylsulfonyl groups and a hydroxyl group, a hydrogen atom, a hydroxyl group or the like; R7 represents a hydrogen atom or a fluorine atom; R8 represents a hydrogen atom, a fluorine atom or the like; R9 represents a hydrogen atom; T represents a single bond, an oxygen atom or a group represented by formula -NH-; Y may be the same or different and each represents a halogen atom or a C1-C6 alkyl group; m represents an integer of 0-3; a saturated ring containing a nitrogen atom may be fused with a cyclopropane ring to form a fused ring; and n represents an integer of 1-3.)

WO/2017/159922	CONJUGATE OF FINASTERIDE WITH PEPTIDE
WO/1994/013691	THIO- AND OXO-AZASTEROIDS, PROCESSES FOR THE PREPARATION THEREOF, USE THEREOF AS ANTIANDROGENS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

OHTSUKA MASAMI (JP)
FUJII KUNIHIKO (JP)
TSUDA TOSHIFUMI (JP)
DOI FUMINAO (JP)
MIYAUCHI SATORU (JP)
ISOBE TAKASHI (JP)

PCT/JP2015/082909

June 02, 2016

November 24, 2015

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DAIICHI SANKYO CO LTD (JP)

C07J73/00; A61K31/58; A61K31/706; A61P1/04; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P43/00

WO2012145254A2

2012-10-26

JP2001524524A	2001-12-04
JPH04230695A	1992-08-19
JPS5448799A	1979-04-17
JP2012506998A	2012-03-22
JPS5076063A	1975-06-21

ISHIBASHI, Koki et al. (JP)
Kimiki Ishibashi (JP)

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