Title:
GPR139 RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/012532
Kind Code:
A1
Abstract:
Provided is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. In addition, further provided are a method for preparing the compound and a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug for treating GPR139 receptor-related diseases.
Inventors:
CHEN JINGCAI (CN)
Application Number:
PCT/CN2023/107260
Publication Date:
January 18, 2024
Filing Date:
July 13, 2023
Export Citation:
Assignee:
NEURONINN BIOSCIENCES CO LTD (CN)
International Classes:
C07C15/02; A61K31/16; A61P25/00; A61P25/22
Domestic Patent References:
| WO2004020402A1 | 2004-03-11 |
Foreign References:
| CN1225083A | 1999-08-04 | |||
| US20070112007A1 | 2007-05-17 |
Other References:
DATABASE Registry 29 September 2004 (2004-09-29), ANONYMOUS: "Propanediamide, N1,N3-bis[(1S)-1-phenylethyl]- (CA INDEX NAME)", XP093129565, retrieved from STNext Database accession no. 753470-76-7
DVORAK CURT A., COATE HEATHER, NEPOMUCENO DIANE, WENNERHOLM MICHELLE, KUEI CHESTER, LORD BRIAN, WOODY DAVID, BONAVENTURE PASCAL, L: "Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 9, 10 September 2015 (2015-09-10), US , pages 1015 - 1018, XP093129554, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00247
FENG SHI, JING KANG SHEN, DANQI CHEN, KARINA FOG, KENNETH THIRSTRUP, MORTEN HENTZER, JENS-JAKOB KARLSSON, VEENA MENON, KENNETH A. : "Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, vol. 2, no. 4, 14 April 2011 (2011-04-14), pages 303 - 306, XP055124814, ISSN: 19485875, DOI: 10.1021/ml100293q
DVORAK CURT A., COATE HEATHER, NEPOMUCENO DIANE, WENNERHOLM MICHELLE, KUEI CHESTER, LORD BRIAN, WOODY DAVID, BONAVENTURE PASCAL, L: "Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 9, 10 September 2015 (2015-09-10), US , pages 1015 - 1018, XP093129554, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00247
FENG SHI, JING KANG SHEN, DANQI CHEN, KARINA FOG, KENNETH THIRSTRUP, MORTEN HENTZER, JENS-JAKOB KARLSSON, VEENA MENON, KENNETH A. : "Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, vol. 2, no. 4, 14 April 2011 (2011-04-14), pages 303 - 306, XP055124814, ISSN: 19485875, DOI: 10.1021/ml100293q
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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