Title:
GENE EDITING SYSTEM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/088175
Kind Code:
A1
Abstract:
Disclosed in the present disclosure are a gRNA targeting VEGFA, a gene editing system, and the use thereof. The gRNA in the present disclosure comprises a guide sequence which has at least 80% sequence identity to any one of SEQ ID NOs: 10-18 and 40-230. The gene editing system in the present disclosure comprises the gRNA of the present disclosure and an encoding sequence thereof, and an RNA-guided nuclease and an encoding sequence thereof.
Inventors:
LIANG JUNBIN (CN)
ZHANG HONG (CN)
XU HUI (CN)
LUO JIAWEN (CN)
JI CUNHUA (CN)
HUANGFU DESHENG (CN)
ZHANG HONG (CN)
XU HUI (CN)
LUO JIAWEN (CN)
JI CUNHUA (CN)
HUANGFU DESHENG (CN)
Application Number:
PCT/CN2023/125680
Publication Date:
May 02, 2024
Filing Date:
October 20, 2023
Export Citation:
Assignee:
GUANGZHOU REFORGENE MEDICINE CO LTD (CN)
International Classes:
C12N15/113; A61K31/7105; A61K48/00; A61P3/10; A61P13/12; A61P17/06; A61P19/02; A61P27/02; A61P35/00; A61P37/02; C12N5/10; C12N15/85
Foreign References:
| CN112662674A | 2021-04-16 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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