Title:
FULLY HUMAN ANTIBODY TARGETING CD123 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/094004
Kind Code:
A1
Abstract:
The invention belongs to the technical field of cell immune engineering, and particularly relates to a fully human antigen binding fragment and single chain fragment variable targeting CD123, and a use thereof. The single chain fragment variable sequence provided by the invention is completely derived from a human antibody gene library. Compared with a murine antibody, a chimeric antibody and a humanized antibody, the immunogenicity of the single chain fragment variable is greatly reduced, and safety can be ensured to the maximum extent in clinical application.
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Inventors:
ZHAO WENXU (CN)
YAO RUINA (CN)
ZHANG CHANGJIANG (CN)
GAO SHIJING (CN)
HUANG YUKANG (CN)
CHEN YUNFAN (CN)
XU YANMIN (CN)
LIU TONGCAN (CN)
ZHAO YONGCHUN (CN)
CHEN JUN (CN)
HUANG XIA (CN)
HONG JUAN (CN)
DAI DEPENG (CN)
QIN LEI (CN)
SHEN JUNJIE (CN)
YAO RUINA (CN)
ZHANG CHANGJIANG (CN)
GAO SHIJING (CN)
HUANG YUKANG (CN)
CHEN YUNFAN (CN)
XU YANMIN (CN)
LIU TONGCAN (CN)
ZHAO YONGCHUN (CN)
CHEN JUN (CN)
HUANG XIA (CN)
HONG JUAN (CN)
DAI DEPENG (CN)
QIN LEI (CN)
SHEN JUNJIE (CN)
Application Number:
PCT/CN2023/128518
Publication Date:
May 10, 2024
Filing Date:
October 31, 2023
Export Citation:
Assignee:
CHONGQING PREC BIOTECH CO LTD (CN)
CHONGQING PRECISION BIOLOGICAL INDUSTRIAL TECH RESEARCH INSTITUTE CO LTD (CN)
CHONGQING PRECISION BIOLOGICAL INDUSTRIAL TECH RESEARCH INSTITUTE CO LTD (CN)
International Classes:
C07K16/28; A61K35/17; A61K39/395; A61P35/00; C07K19/00; C12N5/10; C12N15/13; G01N33/574
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (Scitech Place No.22 Jian Guo Men Wai Ave, Chaoyang District Beijing 4, CN)
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